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Details for receptor: LRP5

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EndoNet ID: ENR00645

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Synonyms

  • LRP5
  • low-density lipoprotein receptor-related protein 5
  • LRP7
  • LDL-receptor-related protein 5

General information

  • Activation of Wnt/β-catenin signaling occurs upon binding of Wnt to the 7-transmembrane domain–spanning frizzled receptor and low-density lipoprotein receptor–related protein 5 and 6 (LRP5/6) coreceptors. [1]
  • LRP5 was seen in Kupffer cells, particularly in those liver specimens with pathological evidence of hepatic congestion and in hepatic stellate cells. [2]
  • In the kidney, the convoluted tubules strongly expressed LRP5, whereas the glomeruli and collecting ducts showed no expression. [2]
  • Involved in the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. [3]
  • Mutations in the Wnt coreceptor lowdensity lipoprotein receptor–related protein 5 (LRP5) are causally linked to alterations in human bone mass. [1]
  • Wnt engagement of Lrp5 induces proliferation and extends the functional lifespan of osteoblasts. [4]
  • In addition to the beta-cells, there were isolated LRP5-expressing cells in the parenchyma of the pancreas which were identified as macrophages. [2]
  • LRP5/6 coreceptor activity is inhibited by members of the sclerostin (SOST gene product) and Dickkopf (Dkk) families, all of which bind LRP5/6. [1]

Links to other resources

UniProt O75197
Ensembl ENST00000294304

Subunit information

Low-density lipoprotein receptor-related protein 5

Sequence 
SPLLLFANR RDVRLVDAG GVKLESTIV 
VSGLEDAAA VDFQFSKGA VYWTDVSEE 
AIKQTYLNQ TGAAVQNVV ISGLVSPDG 
LACDWVGKK LYWTDSETN RIEVANLNG 
TSRKVLFWQ DLDQPRAIA LDPAHGYMY 
WTDWGETPR IERAGMDGS TRKIIVDSD 
IYWPNGLTI DLEEQKLYW ADAKLSFIH 
RANLDGSFR QKVVEGSLT HPFALTLSG 
DTLYWTDWQ TRSIHACNK RTGGKRKEI 
LSALYSPMD IQVLSQERQ PFFHTRCEE 
DNGGCSHLC LLSPSEPFY TCACPTGVQ 
LQDNGRTCK AGAEEVLLL ARRTDLRRI 
SLDTPDFTD IVLQVDDIR HAIAIDYDP 
LEGYVYWTD DEVRAIRRA YLDGSGAQT 
LVNTEINDP DGIAVDWVA RNLYWTDTG 
TDRIEVTRL NGTSRKILV SEDLDEPRA 
IALHPVMGL MYWTDWGEN PKIECANLD 
GQERRVLVN ASLGWPNGL ALDLQEGKL 
YWGDAKTDK IEVINVDGT KRRTLLEDK 
LPHIFGFTL LGDFIYWTD WQRRSIERV 
HKVKASRDV IIDQLPDLM GLKAVNVAK 
VVGTNPCAD RNGGCSHLC FFTPHATRC 
GCPIGLELL SDMKTCIVP EAFLVFTSR 
AAIHRISLE TNNNDVAIP LTGVKEASA 
LDFDVSNNH IYWTDVSLK TISRAFMNG 
SSVEHVVEF GLDYPEGMA VDWMGKNLY 
WADTGTNRI EVARLDGQF RQVLVWRDL 
DNPRSLALD PTKGYIYWT EWGGKPRIV 
RAFMDGTNC MTLVDKVGR ANDLTIDYA 
DQRLYWTDL DTNMIESSN MLGQERVVI 
ADDLPHPFG LTQYSDYIY WTDWNLHSI 
ERADKTSGR NRTLIQGHL DFVMDILVF 
HSSRQDGLN DCMHNNGQC GQLCLAIPG 
GHRCGCASH YTLDPSSRN CSPPTTFLL 
FSQKSAISR MIPDDQHSP DLILPLHGL 
RNVKAIDYD PLDKFIYWV DGRQNIKRA 
KDDGTQPFV LTSLSQGQN PDRQPHDLS 
IDIYSRTLF WTCEATNTI NVHRLSGEA 
MGVVLRGDR DKPRAIVVN AERGYLYFT 
NMQDRAAKI ERAALDGTE REVLFTTGL 
IRPVALVVD NTLGKLFWV DADLKRIES 
CDLSGANRL TLEDANIVQ PLGLTILGK 
HLYWIDRQQ QMIERVEKT TGDKRTRIQ 
GRVAHLTGI HAVEEVSLE EFSAHPCAR 
DNGGCSHIC IAKGDGTPR CSCPVHLVL 
LQNLLTCGE PPTCSPDQF ACATGEIDC 
IPGAWRCDG FPECDDQSD EEGCPVCSA 
AQFPCARGQ CVDLRLRCD GEADCQDRS 
DEADCDAIC LPNQFRCAS GQCVLIKQQ 
CDSFPDCID GSDELMCEI TKPPSDDSP 
AHSSAIGPV IGIILSLFV MGGVYFVCQ 
RVVCQRYAG ANGPFPHEY VSGTPHVPL 
NFIAPGGSQ HGPFTGIAC GKSMMSSVS 
LMGGRGGVP LYDRNHVTG ASSSSSSST 
KATLYPPIL NPPPSPATD PSLYNMDMF 
YSSNIPATA RPYRPYIIR GMAPPTTPC 
STDVCDSDY SASRWKASK YYLDLNSDS 
DPYPPPPTP HSQYLSAED SCPPSPATE 
RSYFHLFPP PPSPCTDSS
UniProt O75197

Binding hormones

  • norrin
  • Dkk1
  • sclerostin

Anatomical structures with this receptor

  • osteoblast

  • adrenal_cortex

  • beta_cell_of_islet_of_Langerhans

  • Kupffer_cell_stellate_cell_of_liver

  • macrophage

  • lipocyte_of_liver

    Induced phenotypes

    • positive regulation of cell-matrix adhesion
      • Cultured rat hepatic stellate cells (HSCs) produce CTGF which is a cell adhesion factor for activated HSCs. LRP is a receptor for CTGF. [5]
      • LRP is utilized by HSCs for binding to CTGF and so this cell surface molecule may be involved in mediating CTGF activity or adhesive signaling during the activation process. [5]

  • kidney

  • hepatocyte

Reference