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Details for receptor: LRP6

EndoNet ID: ENR00646

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  • LRP6
  • low-density lipoprotein receptor-related protein 6
  • LDL-receptor-related protein 6

General information

  • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. [1]
  • Activation of Wnt/β-catenin signaling occurs upon binding of Wnt to the 7-transmembrane domain–spanning frizzled receptor and low-density lipoprotein receptor–related protein 5 and 6 (LRP5/6) coreceptors. [2]
  • LRP5/6 coreceptor activity is inhibited by members of the sclerostin (SOST gene product) and Dickkopf (Dkk) families, all of which bind LRP5/6. [2]

Links to other resources

UniProt O75581
Ensembl ENST00000261349

Binding hormones

  • Dkk1
  • sclerostin

Anatomical structures with this receptor