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Details for receptor: RP105

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  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00651

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Synonyms

  • CD180 antigen
  • lymphocyte antigen 64
  • radioprotective 105 kDa protein
  • RP105

General information

  • Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells. [1]
  • May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B cells. [1]

Links to other resources

UniProt Q99467
Ensembl ENST00000256447

Subunit information

Sequence 
WDQMCIEKE ANKTYNCEN LGLSEIPDT 
LPNTTEFLE FSFNFLPTI HNRTFSRLM 
NLTFLDLTR CQINWIHED TFQSHHQLS 
TLVLTGNPL IFMAETSLN GPKSLKHLF 
LIQTGISNL EFIPVHNLE NLESLYLGS 
NHISSIKFP KDFPARNLK VLDFQNNAI 
HYISREDMR SLEQAINLS LNFNGNNVK 
GIELGAFDS TVFQSLNFG GTPNLSVIF 
NGLQNSTTQ SLWLGTFED IDDEDISSA 
MLKGLCEMS VESLNLQEH RFSDISSTT 
FQCFTQLQE LDLTATHLK GLPSGMKGL 
NLLKKLVLS VNHFDQLCQ ISAANFPSL 
THLYIRGNV KKLHLGVGC LEKLGNLQT 
LDLSHNDIE ASDCCSLQL KNLSHLQTL 
NLSHNEPLG LQSQAFKEC PQLELLDLA 
FTRLHINAP QSPFQNLHF LQVLNLTYC 
FLDTSNQHL LAGLPVLRH LNLKGNHFQ 
DGTITKTNL LQTVGSLEV LILSSCGLL 
SIDQQAFHS LGKMSHVDL SHNSLTCDS 
IDSLSHLKG IYLNLAANS INIISPRLL 
PILSQQSTI NLSHNPLDC TCSNIHFLT 
WYKENLHKL EGSEETTCA NPPSLRGVK 
LSDVKLSCG ITAIGIFFL IVFLLLLAI 
LLFFAVKYL LRWKYQHI

Binding hormones

    Anatomical structures with this receptor

    • spleen

      • Polymerase chain reaction analysis of isolated primary human cell populations confirms that mRNA exists in spleen B lymphocytes and monocytes but not T lymphocytes [2]

    • lymph_node

      • Polymerase chain reaction analysis of isolated primary human cell populations confirms that mRNA exists in spleen B lymphocytes and monocytes but not T lymphocytes [2]

    • appendix

      • Polymerase chain reaction analysis of isolated primary human cell populations confirms that mRNA exists in spleen B lymphocytes and monocytes but not T lymphocytes [2]

    • B-lymphocyte

      Induced phenotypes

      • B-cell activation
        • RP105 may regulate B-cell activation, and RP105-negative B cells produce autoantibodies and take part in pathophysiology of SLE [3]
      • cloning of RP105, a novel murine surface molecule that is found exclusively on mature murine B lymphocytes [2]
      • Consistent with the murine RP105, these laboratories describe the presence of transcript in several B cell lines and in B lymphocytes isolated from human tonsil, indicating that the human gene may also be expressed predominantly by B lymphocytes [2]
    Reference