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Details for receptor: ALK4

EndoNet ID: ENR00654

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  • activin receptor type 1B
  • ALK4
  • activin receptor-like kinase 4
  • ALK-4
  • serine/threonine-protein kinase receptor R2
  • SKR2

General information

  • Forms complexes with ACVR2 and binds cripto.
  • ALK4 and ActRIIA are the primary receptors for Nodal signaling during early development. [1]
  • Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. [2]

Links to other resources

UniProt P36896
Ensembl ENST00000426655

Binding hormones

  • GDF-3
    • We find that GDF3 signaling during embryogenesis can be mediated by the type I receptor ALK4, type II receptors ActRIIA and ActRIIB, and the co-receptor Cripto to activate Smad-dependent reporter genes. [3]
  • GDF-1
    • Receptor reconstitution experiments indicated that GDF-1, like Nodal, can signal through the type I receptors ALK4 and ALK7. [4]

Anatomical structures with this receptor

  • cell_of_endometrium_of_uterus