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Details for receptor: CD14

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EndoNet ID: ENR00655

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Synonyms

  • LPS receptor
  • LPS-R
  • monocyte differentiation antigen CD14
  • myeloid cell-specific leucine-rich glycoprotein
  • CD14

General information

  • Endotoxin activates Kupffer cells to produce receptors (CD-14). [1]
  • mRNAs for CD14, TLR4, and MD2 were upregulated in both in vitro culture-activated HSCs (from normal liver) and in vivo activated HSCs (from HCVinduced cirrhotic liver). [2]

Links to other resources

UniProt P08571
Ensembl ENST00000401743

Subunit information

membrane-bound form

Sequence 
TTPEPCELD DEDFRCVCN FSEPQPDWS 
EAFQCVSAV EVEIHAGGL NLEPFLKRV 
DADADPRQY ADTVKALRV RRLTVGAAQ 
VPAQLLVGA LRVLAYSRL KELTLEDLK 
ITGTMPPLP LEATGLALS SLRLRNVSW 
ATGRSWLAE LQQWLKPGL KVLSIAQAH 
SPAFSCEQV RAFPALTSL DLSDNPGLG 
ERGLMAALC PHKFPAIQN LALRNTGME 
TPTGVCAAL AAAGVQPHS LDLSHNSLR 
ATVNPSAPR CMWSSALNS LNLSFAGLE 
QVPKGLPAK LRVLDLSCN RLNRAPQPD 
ELPEVDNLT LDGNPFLVP GTALPHEGS 
MN

Binding hormones

    Anatomical structures with this receptor

    • Kupffer_cell_stellate_cell_of_liver

    • monocyte

      Influences

      • positive PAF
        • Bacterial lipopolysaccharides (LPS) directly stimulate the synthesis of PAF by a CD14-LPS binding protein (LBP) pathway in monocytes. [3]

    • neutrophil_granulocyte

    • lipocyte_of_liver

      Induced phenotypes

      • regulation of innate immune response
        • Activated human HSCs express TLR4 and its coreceptor CD14.TLR4 signaling in HSCs enhances the recruitment of inflammatory cells and downregulates BMP and activin membrane bound inhibitor (Bambi) for fibrogenic response. [4]
      • Activated human HSCs express TLR4 and its coreceptors MD-2 and CD14. [2]

    • mesangium

      Influences

      • positive PAF
        • Bacterial lipopolysaccharides (LPS) directly stimulate the synthesis of PAF by a CD14-LPS binding protein (LBP) pathway in mesangial cells. [3]

    • neutrophil_granulocyte

    • epithelial_cell_with_microvilli

    • bronchial_epithelial_cell

    Reference