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Details for receptor: Vascular endothelial growth factor receptor 2

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  • Hormones
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EndoNet ID: ENR00668

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Synonyms

  • protein-tyrosine kinase receptor Flk-1
  • VEGFR-2
  • KDR
  • kinase insert domain receptor
  • CD309 antigen
  • KDR/flk-1
  • flk-1/KDR
  • kinase domain region
  • flk-1
  • VEGFR2
  • Vascular endothelial growth factor receptor 2
  • Fetal liver kinase 1

General information

  • Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Links to other resources

UniProt P35968
Ensembl ENST00000263923

Subunit information

Sequence 
ASVGLPSVS LDLPRLSIQ KDILTIKAN 
TTLQITCRG QRDLDWLWP NNQSGSEQR 
VEVTECSDG LFCKTLTIP KVIGNDTGA 
YKCFYRETD LASVIYVYV QDYRSPFIA 
SVSDQHGVV YITENKNKT VVIPCLGSI 
SNLNVSLCA RYPEKRFVP DGNRISWDS 
KKGFTIPSY MISYAGMVF CEAKINDES 
YQSIMYIVV VVGYRIYDV VLSPSHGIE 
LSVGEKLVL NCTARTELN VGIDFNWEY 
PSSKHQHKK LVNRDLKTQ SGSEMKKFL 
STLTIDGVT RSDQGLYTC AASSGLMTK 
KNSTFVRVH EKPFVAFGS GMESLVEAT 
VGERVRIPA KYLGYPPPE IKWYKNGIP 
LESNHTIKA GHVLTIMEV SERDTGNYT 
VILTNPISK EKQSHVVSL VVYVPPQIG 
EKSLISPVD SYQYGTTQT LTCTVYAIP 
PPHHIHWYW QLEEECANE PSQAVSVTN 
PYPCEEWRS VEDFQGGNK IEVNKNQFA 
LIEGKNKTV STLVIQAAN VSALYKCEA 
VNKVGRGER VISFHVTRG PEITLQPDM 
QPTEQESVS LWCTADRST FENLTWYKL 
GPQPLPIHV GELPTPVCK NLDTLWKLN 
ATMFSNSTN DILIMELKN ASLQDQGDY 
VCLAQDRKT KKRHCVVRQ LTVLERVAP 
TITGNLENQ TTSIGESIE VSCTASGNP 
PPQIMWFKD NETLVEDSG IVLKDGNRN 
LTIRRVRKE DEGLYTCQA CSVLGCAKV 
EAFFIIEGA QEKTNLEII ILVGTAVIA 
MFFWLLLVI ILRTVKRAN GGELKTGYL 
SIVMDPDEL PLDEHCERL PYDASKWEF 
PRDRLKLGK PLGRGAFGQ VIEADAFGI 
DKTATCRTV AVKMLKEGA THSEHRALM 
SELKILIHI GHHLNVVNL LGACTKPGG 
PLMVIVEFC KFGNLSTYL RSKRNEFVP 
YKTKGARFR QGKDYVGAI PVDLKRRLD 
SITSSQSSA SSGFVEEKS LSDVEEEEA 
PEDLYKDFL TLEHLICYS FQVAKGMEF 
LASRKCIHR DLAARNILL SEKNVVKIC 
DFGLARDIY KDPDYVRKG DARLPLKWM 
APETIFDRV YTIQSDVWS FGVLLWEIF 
SLGASPYPG VKIDEEFCR RLKEGTRMR 
APDYTTPEM YQTMLDCWH GEPSQRPTF 
SELVEHLGN LLQANAQQD GKDYIVLPI 
SETLSMEED SGLSLPTSP VSCMEEEEV 
CDPKFHYDN TAGISQYLQ NSKRKSRPV 
SVKTFEDIP LEEPEVKVI PDDNQTDSG 
MVLASEELK TLEDRTKLS PSFGGMVPS 
KSRESVASE GSNQTSGYQ SGYHSDDTD 
TTVYSSEEA ELLKLIEIG VQTGSTAQI 
LQPDSGTTL SSPPV

Binding hormones

  • VEGFC
  • VEGF-121
  • VEGF-165
    • Tissue inhibitor of metalloproteinases-3 (TIMP3) blocks the binding of VEGF to VEGF receptor-2 and inhibits downstream signaling and angiogenesis. [1]
  • VEGFD
  • VEGFE
  • pigment epithelium-derived factor
  • gremlin-1
    • Gremlin binds with high affinity to the important vascular endothelial growth factor (VEGF) receptor in endothelial cells, VEGF receptor-2 (VEGFR2). [2]

Anatomical structures with this receptor

  • bone_marrow

    Induced phenotypes

    • angiogenesis
      • Recruitment of circulating endothelial precursors to sites of active angiogenesis is mediated through VEGFR2. [3]

  • sinusoidal_endothelial_cell

    Induced phenotypes

    • regulation of endothelial cell differentiation
      • VEGFR2 signaling is required for capillary tube formation, it regulates the differentiation of endothelial cells into capillary tubes. [4]

  • microvascularendothelial_cell

    Influences

    • positive von Willebrand factor
      • VEGF receptor-2 (VEGFR2), but not VEGFR1, is responsible for VEGF-induced release of von Willebrand factor (vWF), a major marker of endothelial Weibel-Palade bodies WPBs. [5]

  • Müllers_radial_cell_of_retina

    Induced phenotypes

    • regulation of neural retina development
      • Extravascular VEGFR-1 and -2 are necessary for normal neural retinal development independent of vascular development. [6]
      • Peripheral retina is normally avascular at birth and becomes vascularized over the first 2 weeks after birth. [7]
      • Inhibition of VEGFR-1 and -2 in vivo inhibits development of the nonvascularized immature retina, resulting in cell loss in the inner retina, including the inner nuclear layer containing Muller cells and the ganglion cell layer containing astrocytes. [6]
    • Isolated retinal Muller cells express both VEGF1 and VEGFR2 receptors. [6]

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    Influences

    • negative VEGF-165
Reference