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Details for receptor: Vascular endothelial growth factor receptor 1

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EndoNet ID: ENR00669

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Synonyms

  • tyrosine-protein kinase FRT
  • vascular permeability factor receptor
  • tyrosine-protein kinase receptor FLT
  • Flt-1
  • VEGFR-1
  • VEGFR1
  • Fms-like tyrosine kinase 1
  • Vascular endothelial growth factor receptor 1

General information

Links to other resources

UniProt P17948
Ensembl ENST00000282397

Subunit information

Flt1

Sequence 
SKLKDPELS LKGTQHIMQ AGQTLHLQC 
RGEAAHKWS LPEMVSKES ERLSITKSA 
CGRNGKQFC STLTLNTAQ ANHTGFYSC 
KYLAVPTSK KKETESAIY IFISDTGRP 
FVEMYSEIP EIIHMTEGR ELVIPCRVT 
SPNITVTLK KFPLDTLIP DGKRIIWDS 
RKGFIISNA TYKEIGLLT CEATVNGHL 
YKTNYLTHR QTNTIIDVQ ISTPRPVKL 
LRGHTLVLN CTATTPLNT RVQMTWSYP 
DEKNKRASV RRRIDQSNS HANIFYSVL 
TIDKMQNKD KGLYTCRVR SGPSFKSVN 
TSVHIYDKA FITVKHRKQ QVLETVAGK 
RSYRLSMKV KAFPSPEVV WLKDGLPAT 
EKSARYLTR GYSLIIKDV TEEDAGNYT 
ILLSIKQSN VFKNLTATL IVNVKPQIY 
EKAVSSFPD PALYPLGSR QILTCTAYG 
IPQPTIKWF WHPCNHNHS EARCDFCSN 
NEESFILDA DSNMGNRIE SITQRMAII 
EGKNKMAST LVVADSRIS GIYICIASN 
KVGTVGRNI SFYITDVPN GFHVNLEKM 
PTEGEDLKL SCTVNKFLY RDVTWILLR 
TVNNRTMHY SISKQKMAI TKEHSITLN 
LTIMNVSLQ DSGTYACRA RNVYTGEEI 
LQKKEITIR DQEAPYLLR NLSDHTVAI 
SSSTTLDCH ANGVPEPQI TWFKNNHKI 
QQEPGIILG PGSSTLFIE RVTEEDEGV 
YHCKATNQK GSVESSAYL TVQGTSDKS 
NLELITLTC TCVAATLFW LLLTLLIRK 
MKRSSSEIK TDYLSIIMD PDEVPLDEQ 
CERLPYDAS KWEFARERL KLGKSLGRG 
AFGKVVQAS AFGIKKSPT CRTVAVKML 
KEGATASEY KALMTELKI LTHIGHHLN 
VVNLLGACT KQGGPLMVI VEYCKYGNL 
SNYLKSKRD LFFLNKDAA LHMEPKKEK 
MEPGLEQGK KPRLDSVTS SESFASSGF 
QEDKSLSDV EEEEDSDGF YKEPITMED 
LISYSFQVA RGMEFLSSR KCIHRDLAA 
RNILLSENN VVKICDFGL ARDIYKNPD 
YVRKGDTRL PLKWMAPES IFDKIYSTK 
SDVWSYGVL LWEIFSLGG SPYPGVQMD 
EDFCSRLRE GMRMRAPEY STPEIYQIM 
LDCWHRDPK ERPRFAELV EKLGDLLQA 
NVQQDGKDY IPINAILTG NSGFTYSTP 
AFSEDFFKE SISAPKFNS GSSDDVRYV 
NAFKFMSLE RIKTFEELL PNATSMFDD 
YQGDSSTLL ASPMLKRFT WTDSKPKAS 
LKIDLRVTS KSKESGLSD VSRPSFCHS 
SCGHVSEGK RRFTYDHAE LERKIACCS 
PPPDYNSVV LYSTPPI
UniProt P17948-1

Binding hormones

  • VEGFB
    • VEGF-B is a ligand for VEGFR-1 and Nrp-1. Neither isoform binds VEGFR-2 or VEGFR-3 [1]
  • PlGF-3
    • PIGF binds to receptor VEGFR-1/FLT1. [2]
  • VEGF-121
  • VEGF-165
  • PlGF-1
    • PLGF-1, missing the heparin binding domain, binds only FLT-1(=VEGFR-1) [3]
  • PlGF-2
    • PGF-2 has a 21-amino acid heparin binding domain and is also able to bind both of the known PGF receptors: neuropilin-1 (Nrp-1) and FLT-1 (=VEGFR-1) [3]

Anatomical structures with this receptor

  • bone_marrow

    Induced phenotypes

    • hematopoiesis
      • Inhibition of VEGFR1, but not VEGFR2, blockes HSC cell cycling, differentiation and hematopoietic recovery after bone marrow suppression. Placental growth factor (PlGF), which signals through VEGFR1, restored early and late phases of hematopoiesis following bone marrow suppression. PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative bone marrow microenvironment, favoring differentiation, mobilization and reconstitution of hematopoiesis. [4]

  • lung

  • placenta

    Induced phenotypes

    • preeclampsia
      • Increased levels of soluble VEGFR1 variant (sFlt1) in the placenta and reduced levels of PlGF predict the subsequent development of preeclampsia. [5]

  • kidney

  • heart

    Induced phenotypes

    • heart development
      • Moderate overexpression of VEGF1 from its endogenous locus results in aberrant heart development and lethality at E12.5-14, which shows essential role of regulated signalling during development. [6]

  • brain

  • vascularendothelial_cell

    Induced phenotypes

    • vasculogenesis
      • VEGF is a crucial regulator of vasculogenesis. [7]
    • vascular permeability
      • VEGF is a crucial regulator of vascular permeability. [7]

  • sinusoidal_endothelial_cell

    Induced phenotypes

    • negative regulation of apoptosis
      • VEGFR1 signaling is critical for endothelial cell survival. [8]
      • VEGF enhances the survival of endothelial cells by regulating the activity of the anti-apoptotic Bcl-2 and inhibiting caspase-mediated cell death. [8]

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    Influences

    • positive interleukin 6
      • VEGF-stimulated interleukin-6 release from endothelium is selectively mediated through VEGFR1. [9]

    Induced phenotypes

    • regulation of angiogenesis
      • VEGF is a crucial regulator of angiogenesis.
    • positive regulation of endothelial cell proliferation
      • VEGF promotes proliferation, migration, and survival of endothelial cells. [10]
    • positive regulation of endothelial cell migration
      • VEGF promotes proliferation, migration, and survival of endothelial cells. [10]
    • inflammation
      • VEGF contributes to imflammation independent of its angiogenic functions. [11]

  • Müllers_radial_cell_of_retina

    Induced phenotypes

    • regulation of neural retina development
      • Extravascular VEGFR-1 and -2 are necessary for normal neural retinal development independent of vascular development. [12]
      • Peripheral retina is normally avascular at birth and becomes vascularized over the first 2 weeks after birth. [13]
      • Inhibition of VEGFR-1 and -2 in vivo inhibits development of the nonvascularized immature retina, resulting in cell loss in the inner retina, including the inner nuclear layer containing Muller cells and the ganglion cell layer containing astrocytes. [12]
    • Isolated retinal Muller cells express both VEGF1 and VEGFR2 receptors. [12]

  • smooth_muscle

    Induced phenotypes

    • vessel maturation
      • PlGF also acts on VEGFR-1-expressing smooth muscle cells, thus promoting vessel maturation. [14]
    • These findings demonstrate that vascular SMCs express functional flt-1 receptors after arterial injury. [15]
Reference