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Details for receptor: neuropilin 1

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EndoNet ID: ENR00670

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Synonyms

  • NRP1
  • NRP-1
  • NRP 1
  • neuropilin 1
  • CD304 antigen
  • NRP
  • VEGF165R
  • Vascular endothelial growth factor 165 receptor
  • VEGF 165 receptor
  • SNRP1
  • blood dendritic cell antigen 4
  • NP-1
  • neuropilin-1

General information

  • Neuropilin, a type I transmembrane protein implicated in aspects of neurodevelopment, is a Sema III receptor. [1]
  • Neuropilin-1 is a placenta growth factor-2 receptor. [2]
  • Membrane bound isoform 1 and soluble isoform 2.
  • Neuropilin-1 (NRP1) is a 130-kDa transmembrane receptor for semaphorins, mediators of neuronal guidance, and for vascular endothelial growth factor 165 (VEGF(165)), an angiogenesis factor. [3]

Links to other resources

UniProt O14786
Ensembl ENST00000455749

Subunit information

Neuropilin-1

Sequence 
FRNDKCGDT IKIESPGYL TSPGYPHSY 
HPSEKCEWL IQAPDPYQR IMINFNPHF 
DLEDRDCKY DYVEVFDGE NENGHFRGK 
FCGKIAPPP VVSSGPFLF IKFVSDYET 
HGAGFSIRY EIFKRGPEC SQNYTTPSG 
VIKSPGFPE KYPNSLECT YIVFAPKMS 
EIILEFESF DLEPDSNPP GGMFCRYDR 
LEIWDGFPD VGPHIGRYC GQKTPGRIR 
SSSGILSMV FYTDSAIAK EGFSANYSV 
LQSSVSEDF KCMEALGME SGEIHSDQI 
TASSQYSTN WSAERSRLN YPENGWTPG 
EDSYREWIQ VDLGLLRFV TAVGTQGAI 
SKETKKKYY VKTYKIDVS SNGEDWITI 
KEGNKPVLF QGNTNPTDV VVAVFPKPL 
ITRFVRIKP ATWETGISM RFEVYGCKI 
TDYPCSGML GMVSGLISD SQITSSNQG 
DRNWMPENI RLVTSRSGW ALPPAPHSY 
INEWLQIDL GEEKIVRGI IIQGGKHRE 
NKVFMRKFK IGYSNNGSD WKMIMDDSK 
RKAKSFEGN NNYDTPELR TFPALSTRF 
IRIYPERAT HGGLGLRME LLGCEVEAP 
TAGPTTPNG NLVDECDDD QANCHSGTG 
DDFQLTGGT TVLATEKPT VIDSTIQSE 
FPTYGFNCE FGWGSHKTF CHWEHDNHV 
QLKWSVLTS KTGPIQDHT GDGNFIYSQ 
ADENQKGKV ARLVSPVVY SQNSAHCMT 
FWYHMSGSH VGTLRVKLR YQKPEEYDQ 
LVWMAIGHQ GDHWKEGRV LLHKSLKLY 
QVIFEGEIG KGNLGGIAV DDISINNHI 
SQEDCAKPA DLDKKNPEI KIDETGSTP 
GYEGEGEGD KNISRKPGN VLKTLEPIL 
ITIIAMSAL GVLLGAVCG VVLYCACWH 
NGMSERNLS ALENYNFEL VDGVKLKKD 
KLNTQSTYS EA
UniProt O14786-1

Binding hormones

  • SP
  • VEGFB
    • VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. [4]
  • PlGF-2
    • Np-1 also serves as a receptor for the heparin-binding form of placenta growth factor (PlGF), PlGF-2, and for VEGF-B. [5]
  • semaphorin 3A
    • Sema3a signaling is mediated by a complex of binding receptor neuropilin 1 and the signaling receptors plexinA1 or A3. [6]
  • VEGF-165
    • Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. [4]
  • semaphorin 3B
    • This presumably occurs because SEMA3B and VEGF165 compete for neuropilin receptors on the tumor cell surface [7]
    • SEMA3B inhibits the PI3K/Akt pathway acting through Np-1 receptors in cancer cells. [7]
  • semaphorin 3D

Anatomical structures with this receptor

  • mammary_gland

  • heart

    Induced phenotypes

    • patterning of blood vessels
      • Semaphorin 3a is a chemorepellent with multiple guidance functions, including cardiac vescular patterning and branching morphogenesis. [8]

  • placenta

  • lung

  • skeleton_muscle

  • kidney

    Induced phenotypes

    • inhibition of ureteric bud branching
      • Sema3a inhibits ureteric bud brancing by downregulation of glia-cell-line-derived neurotrophic factor. [9]
    • excess of endothelial cells
      • Sema3a gene deletion causes excess endothelial cells. [8]
    • podocyte differentiation
      • Downregulation of WT1 and nephrin by Sema3a overexpression, and downregulation of PAX2 in Sema3a-/- mice, suggest that Sema3a might function as a modifier of PAX2 and WT1 signaling during podocyte differentiation. Thus, Sema3a may act as a negative regulator of podocyte differentiation pathways by inducing downregulation of WT1 and nephrin. [8]
    • cell differentiation
      • Sema3a overexpression in podocytes during kidney organogenesis leads to abnormal podocyte differentiation with a complete absence of slit diaphragms. [8]
      • Podocyte effacement might represent a final common pathway that occurs with disruption of podocyte differentiation. [8]
    • acute nephrotic range proteinuria
      • Administration of recombinant Sema3a to wild-type mice induces foot process effacement and fusion, endothelial cell swelling and reversible albuminuria, representing a novel mechanism for proteinuria.

  • pancreas

  • brain

    Induced phenotypes

    • axon guidance
      • Semaphorin 3a is a chemorepellent with multiple guidance functions, including axon pathfinding. [8]

  • blood_vessel

    Induced phenotypes

    • excess of capillary formation
      • Overexpression of neuropilin 1 results in embryonic lethality owing to an excess of capillary formation. [10]
    • patterning of blood vessels
      • Semaphorin3a is a chemorepellent with multiple guidance functions, including peripheral vascular patterning and branching morphogenesis. [8]

  • podocyte

  • bone_marrow

  • glomerulus

    Induced phenotypes

    • induction of podocyte apoptosis
      • In cultured podocytes, recombinant Sema3a downregulates podocin expression, decreases the interaction between slit diaphragm proteins podocin, nephrin and CD2AP and induces podocyte apoptosis through inhibition of the phosphorylation of AKT. [11]
    • formation of glomerular filter barrier
      • Sema3a plays a role in the formation of the glomerular filtration barrier. [8]
      • Sema3a negatively regulates endothelial cell survival during glomerular development and a tight regulation of Sema3a dosage is necessary for normal glomerular vascularization. [8]
    • inhibition of glomerular capillary lumen development
      • Sema3a gene deletion causes poor glomerular capillary lumen development. [8]
    • patterning of blood vessels
      • Sema3a gene deletion causes defective renal vascular patterning.
    • positive regulation of apoptosis
      • Sema3a overexpression in podocytes during organogenesis leads to glomerular hypoplasia and glomerular endothelial apoptosis. [8]
Reference