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Details for receptor: CCR7

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EndoNet ID: ENR00675

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For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • CCR7
  • MIP-3 beta receptor
  • EBV-induced G-protein coupled receptor 1
  • EBI1
  • BLR2
  • CD197 antigen

General information

  • Expressed in various lymphoid tissues and activated B- and T-lymphocytes. [1]

Links to other resources

UniProt P32248
Ensembl ENST00000246657

Subunit information

Sequence 
DEVTDDYIG DNTTVDYTL FESLCSKKD 
VRNFKAWFL PIMYSIICF VGLLGNGLV 
VLTYIYFKR LKTMTDTYL LNLAVADIL 
FLLTLPFWA YSAAKSWVF GVHFCKLIF 
AIYKMSFFS GMLLLLCIS IDRYVAIVQ 
AVSAHRHRA RVLLISKLS CVGIWILAT 
VLSIPELLY SDLQRSSSE QAMRCSLIT 
EHVEAFITI QVAQMVIGF LVPLLAMSF 
CYLVIIRTL LQARNFERN KAIKVIIAV 
VVVFIVFQL PYNGVVLAQ TVANFNITS 
STCELSKQL NIAYDVTYS LACVRCCVN 
PFLYAFIGV KFRNDLFKL FKDLGCLSQ 
EQLRQWSSC RHIRRSSMS VEAETTTTF 
SP

Binding hormones

  • MIP-3 beta
  • CCL21
    • CCL21 binds to CCR7. [1]

Anatomical structures with this receptor

  • lymphoid_tissue

  • B-lymphocyte

  • T-lymphocyte

  • dendritic_cell_in_lymphoid_tissues

    Induced phenotypes

    • dendritic cell chemotaxis
      • Migration of DC to lymph nodes is regulated by chemokine receptor CCR7, expressed on mature DC, and the CCR7 ligands CCL19 and CCL21. [2]
    • Chemokine receptor CCR7 is expressed on mature DC. [2]
Reference