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Details for receptor: TNFR2

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EndoNet ID: ENR00679

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Synonyms

  • TNFR2
  • p75 TNF receptor
  • tumor necrosis factor receptor 2
  • TNF-R2
  • tumor necrosis factor receptor type II
  • TNFRSF1B
  • CD120b
  • p75
  • TNFR80
  • TNF-R75
  • TNFBR
  • p75TNFR

General information

  • The potent osteoclastogenic agent, tumor necrosis factor-alpha (TNF), exerts its biological effects via two receptors, namely TNF receptors 1 (p55r) and 2 (p75r), each present on osteoclast precursors. [1]
  • hematopoietically restricted [2]

Links to other resources

UniProt P20333
Ensembl ENST00000400863

Binding hormones

  • TNF-alpha

Anatomical structures with this receptor

  • osteoclast

  • Kupffer_cell_stellate_cell_of_liver

  • neutrophil_granulocyte

  • lipocyte_of_liver

    Influences

    • positive RANTES
      • Hepatic stellate cells secrete RANTES after stimulation with TNF-alpha, IL-1beta, and CD40L in an inhibitor-kappaB (I kappa B)kinase (IKK)2/NF kappaB- and JNK-dependent manner. [3]

  • hepatocyte

    Influences

    • positive TGF-alpha
      • In primary hepatocyte cultures, TNF not only potentiates growth factor-stimulated proliferation, but acts as a mitogen itself through the induced release of autocrine transforming growth factor- (TGF-) and its activation of serine-threonine protein kinase B (PKB)/Akt and extracellular signal-regulated kinase (ERK). [4]
    • positive IL-1 beta
      • Induced IL-1alpha release from hepatocyte is contingent on both TNF and autocrine TGF-alpha. [4]
    • positive IL-1 alpha
      • Induced IL-1alpha release from hepatocyte is contingent on both TNF and autocrine TGF-alpha. [4]
    • positive IL-1RA
      • TNF induces the release of IL-1ra. [4]

    Induced phenotypes

    • antagonizing IL-1alpha/beta ligand activity
      • TNF induces the release of IL-1ra, which antagonizes IL-1alpha/beta ligand activity. [4]
    • positive regulation of cell proliferation
      • TNF-induced autocrine TGF- and IL-1alpha/beta contribute to multiple intracellular signaling pathways that govern hepatocyte proliferation. [4]
      • Autocrine TGF-alpha regulates pro-proliferative/antiapoptotic signaling through the ERK and, in the absence of Adenoviral infection, Akt pathways. [5]
    • positive regulation of apoptosis
      • TNF-induced autocrine TGF- and IL-1alpha/beta contribute to multiple intracellular signaling pathways that govern hepatocyte apoptosis. [4]
      • Autocrine IL-1alpha/beta regulates proapoptotic signaling through JNK and p38 pathways. [4]

  • adipose_tissue

    Influences

    • positive leptin
      • Leptin secretion is regulated by TNF-alpha posttranslationally. This secretagogue-like activity is consistent with the existence of regulatable pools of leptin and may contribute in part to the insulin resistance properties of TNF-alpha as well as the adipostatic mechanisms of leptin. [6]
Reference