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Details for receptor: CXCR3

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EndoNet ID: ENR00682

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Synonyms

  • CXCR3
  • interferon-inducible protein 10 receptor
  • IP-10 receptor
  • C-X-C chemokine receptor type 3

General information

  • Receptor for CXCL9, CXCL10 and CXCL11, mediates the proliferation of human mesangial cells. [1]

Links to other resources

UniProt P49682
Ensembl ENST00000373693

Subunit information

CXCR3-A

Sequence 
MVLEVSDHQ VLNDAEVAA LLENFSSSY 
DYGENESDS CCTSPPCPQ DFSLNFDRA 
FLPALYSLL FLLGLLGNG AVAAVLLSR 
RTALSSTDT FLLHLAVAD TLLVLTLPL 
WAVDAAVQW VFGSGLCKV AGALFNINF 
YAGALLLAC ISFDRYLNI VHATQLYRR 
GPPARVTLT CLAVWGLCL LFALPDFIF 
LSAHHDERL NATHCQYNF PQVGRTALR 
VLQLVAGFL LPLLVMAYC YAHILAVLL 
VSRGQRRLR AMRLVVVVV VAFALCWTP 
YHLVVLVDI LMDLGALAR NCGRESRVD 
VAKSVTSGL GYMHCCLNP LLYAFVGVK 
FRERMWMLL LRLGCPNQR GLQRQPSSS 
RRDSSWSET SEASYSGL
UniProt P49682-1

Binding hormones

  • CXCL11
  • MIG
  • IP-10
  • Emap2
    • In this study, we demonstrate that the full-length EMAP II can bind and signal through the chemokine receptor CXCR3. [2]
  • PF-4
    • The alternative spliced isoform B of the CXC3 receptor (=CXCR3-B) acts as a functional receptor for CXCL4 (platelet factor 4). [3]

Anatomical structures with this receptor

  • monocyte

  • killer_cell

Reference