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Details for receptor: CCR1

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EndoNet ID: ENR00685

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For an hormone that would be: 

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Synonyms

  • CCR1
  • C-C chemokine receptor type 1
  • CC-CKR-1
  • macrophage inflammatory protein 1-alpha receptor
  • MIP-1alpha-R
  • RANTES-R
  • HM145
  • LD78 receptor
  • CD191 antigen

General information

  • Monocytes express an array of inflammatory chemokine receptors, including CCR1, CCR2, CCR5 and the interleukin (IL)-8 (also called CXCL85) receptors CXCR1 and CXCR2. [1]
  • Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1. [2]

Links to other resources

UniProt P32246
Ensembl ENST00000296140

Subunit information

Sequence 
METPNTTED YDTTTEFDY GDATPCQKV 
NERAFGAQL LPPLYSLVF VIGLVGNIL 
VVLVLVQYK RLKNMTSIY LLNLAISDL 
LFLFTLPFW IDYKLKDDW VFGDAMCKI 
LSGFYYTGL YSEIFFIIL LTIDRYLAI 
VHAVFALRA RTVTFGVIT SIIIWALAI 
LASMPGLYF SKTQWEFTH HTCSLHFPH 
ESLREWKLF QALKLNLFG LVLPLLVMI 
ICYTGIIKI LLRRPNEKK SKAVRLIFV 
IMIIFFLFW TPYNLTILI SVFQDFLFT 
HECEQSRHL DLAVQVTEV IAYTHCCVN 
PVIYAFVGE RFRKYLRQL FHRRVAVHL 
VKWLPFLSV DRLERVSST SPSTGEHEL 
SAGF

Binding hormones

  • MIP-1 delta
  • MPIF-1
  • MCP-3
  • MIP-1 beta
  • RANTES
  • MIP-1 alpha
  • HCC-1
    • Acts via receptors that also recognize MIP-1 alpha. [2]
    • Is a ligand for CCR1, CCR3 and CCR5. [3]
    • HCC-1 is active on monocytes, and our data suggest that CCR1 is the main receptor involved in the functional response of these cells [3]

Anatomical structures with this receptor

  • monocyte

Reference