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Details for receptor: CCR3

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EndoNet ID: ENR00688

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Synonyms

  • CCR3
  • eosinophil eotaxin receptor
  • CD193 antigen
  • CKR3
  • C-C chemokine receptor type 3

General information

  • Allergic reactions are characterized by the infiltration of tissues by activated eosinophils, Th2 lymphocytes, and basophils. The beta-chemokine receptor CCR3, which recognizes the ligands eotaxin, eotaxin-2, monocyte chemotactic protein (MCP) 3, MCP4, and RANTES, plays a central role in this process, and antagonists to this receptor could have potential therapeutic use in the treatment of allergy.
  • Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. [1]

Links to other resources

UniProt P51677
Ensembl ENST00000457243

Subunit information

Sequence 
MTTSLDTVE TFGTTSYYD DVGLLCEKA 
DTRALMAQF VPPLYSLVF TVGLLGNVV 
VVMILIKYR RLRIMTNIY LLNLAISDL 
LFLVTLPFW IHYVRGHNW VFGHGMCKL 
LSGFYHTGL YSEIFFIIL LTIDRYLAI 
VHAVFALRA RTVTFGVIT SIVTWGLAV 
LAALPEFIF YETEELFEE TLCSALYPE 
DTVYSWRHF HTLRMTIFC LVLPLLVMA 
ICYTGIIKT LLRCPSKKK YKAIRLIFV 
IMAVFFIFW TPYNVAILL SSYQSILFG 
NDCERSKHL DLVMLVTEV IAYSHCCMN 
PVIYAFVGE RFRKYLRHF FHRHLLMHL 
GRYIPFLPS EKLERTSSV SPSTAEPEL 
SIVF

Binding hormones

  • MIP-1 delta
  • MCP-3
  • eotaxin
  • eotaxin-2
  • eotaxin-3
  • PARC
    • MIP4 as an CCR3-antagonist is able to inhibit CCR3-mediated eosinophil chemotaxis. [2]
  • MCP-4
  • RANTES
  • CCL28
  • IP-10
  • HCC-1
    • Is a ligand for CCR1, CCR3 and CCR5

Anatomical structures with this receptor

  • epithelial_cell_with_microvilli

  • eosinophil_granulocyte

  • monocyte

  • neutrophil_granulocyte

Reference