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Details for receptor: CCR6

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EndoNet ID: ENR00690

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Synonyms

  • CCR6
  • C-C chemokine receptor type 6
  • CCR-6
  • LARC receptor
  • CC-CKR-6
  • GPRCY4
  • chemokine receptor-like 3
  • DRY6
  • G-protein coupled receptor 29
  • CD196 antigen

General information

Links to other resources

UniProt P51684
Ensembl ENST00000400926

Binding hormones

  • BD-2
    • β-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6. [1]
  • MIP-3 alpha
  • BD-1
    • β-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6. [1]

Anatomical structures with this receptor

  • B-lymphocyte

    Induced phenotypes

    • chemotaxis of lymphocytes
      • CC-chemokine receptor (CCR) 6 is the only known receptor for macrophage inflammatory protein (MIP)-3alpha, a CC chemokine chemotactic for lymphocytes and dendritic cells. [2]

  • memory_cell_T

    Induced phenotypes

    • chemotaxis of lymphocytes
      • CC-chemokine receptor (CCR) 6 is the only known receptor for macrophage inflammatory protein (MIP)-3alpha, a CC chemokine chemotactic for lymphocytes and dendritic cells. [2]
    • We found that CCR6 was expressed within the T-cell group only on memory T cells. ccordingly, chemotaxis of T cells to MIP-3α was limited to memory cells. [2]

  • dendritic_cell_in_lymphoid_tissues

    Induced phenotypes

    • dendritic cell chemotaxis
      • β-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6. [1]
      • CC-chemokine receptor (CCR) 6 is the only known receptor for macrophage inflammatory protein (MIP)-3alpha, a CC chemokine chemotactic for lymphocytes and dendritic cells. [2]
    • human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. [1]

  • neutrophil_granulocyte

    Induced phenotypes

    • Neutrophil chemotaxis
      • hBD-2 induces the chemotaxis of TNF-α-pretreated neutrophils. [3]
      • Our results suggest that hBD-2 and MIP-3α share CCR6 as their main receptor on neutrophils; however, neutrophils may possess an additional receptor(s) for hBD-2. [3]
    • Cytokine-activated PMNLs (polymorphonuclear leukocytes) expressed functional CCR6. [4]
Reference