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Details for receptor: PPAR-gamma2

EndoNet ID: ENR00693

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Synonyms

  • PPAR gamma 2
  • PPAR-gamma2
  • peroxisome-proliferator-activated receptor gamma 2

General information

  • Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also are detectable in placenta, lung and ovary. [1]
  • Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. [1]
  • PPARgamma2, harboring an additional 30 amino acids at its N-terminal end, is expressed specifically in adipocytes, whereas PPARgamma1 is also relatively abundant in macrophages, colon epithelia, and endothelium. [2]

Links to other resources

UniProt P37231-1
Ensembl ENST00000455517

Subunit information

PPAR-gamma isoform 2

Sequence
MGETLGDSP IDPESDSFT DTLSANISQ 
EMTMVDTEM PFWPTNFGI SSVDLSVME 
DHSHSFDIK PFTTVDFSS ISTPHYEDI 
PFTRTDPVV ADYKYDLKL QEYQSAIKV 
EPASPPYYS EKTQLYNKP HEEPSNSLM 
AIECRVCGD KASGFHYGV HACEGCKGF 
FRRTIRLKL IYDRCDLNC RIHKKSRNK 
CQYCRFQKC LAVGMSHNA IRFGRMPQA 
EKEKLLAEI SSDIDQLNP ESADLRALA 
KHLYDSYIK SFPLTKAKA RAILTGKTT 
DKSPFVIYD MNSLMMGED KIKFKHITP 
LQEQSKEVA IRIFQGCQF RSVEAVQEI 
TEYAKSIPG FVNLDLNDQ VTLLKYGVH 
EIIYTMLAS LMNKDGVLI SEGQGFMTR 
EFLKSLRKP FGDFMEPKF EFAVKFNAL 
ELDDSDLAI FIAVIILSG DRPGLLNVK 
PIEDIQDNL LQALELQLK LNHPESSQL 
FAKLLQKMT DLRQIVTEH VQLLQVIKK 
TETDMSLHP LLQEIYKDL Y

Binding hormones

    Anatomical structures with this receptor

    • adipose_tissue

      Induced phenotypes

      • regulation of fat cell differentiation
        • PPAR╬│ expression is observed in adipose tissue in rodents. Its expression is induced early in differentiation of 3T3-L1 preadipocytes into adipocytes, and its overexpression in fibroblasts induces them to differentiate into adipocytes. [3]
    • spleen

    • heart

      Induced phenotypes

      • regulation of glucose homeostasis
        • PPAR-gamma is expressed in the heart, one tissue where most of the insulin-stimulated glucose uptake occurs. [4]
    • placenta

    • lung

    • ovary

    • fat_cell

      Induced phenotypes

      • regulation of glucose homeostasis
        • PPAR-gamma is expressed in human fat, one tissue where most of the insulin-stimulated glucose uptake occurs. [4]
    Reference