Status
Please wait ...

Details for receptor: PPAR-gamma2

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00693

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • PPAR gamma 2
  • PPAR-gamma2
  • peroxisome-proliferator-activated receptor gamma 2

General information

  • Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also are detectable in placenta, lung and ovary. [1]
  • Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. [1]
  • PPARgamma2, harboring an additional 30 amino acids at its N-terminal end, is expressed specifically in adipocytes, whereas PPARgamma1 is also relatively abundant in macrophages, colon epithelia, and endothelium. [2]

Links to other resources

UniProt P37231-1
Ensembl ENST00000455517

Subunit information

PPAR-gamma isoform 2

Sequence 
MGETLGDSP IDPESDSFT DTLSANISQ 
EMTMVDTEM PFWPTNFGI SSVDLSVME 
DHSHSFDIK PFTTVDFSS ISTPHYEDI 
PFTRTDPVV ADYKYDLKL QEYQSAIKV 
EPASPPYYS EKTQLYNKP HEEPSNSLM 
AIECRVCGD KASGFHYGV HACEGCKGF 
FRRTIRLKL IYDRCDLNC RIHKKSRNK 
CQYCRFQKC LAVGMSHNA IRFGRMPQA 
EKEKLLAEI SSDIDQLNP ESADLRALA 
KHLYDSYIK SFPLTKAKA RAILTGKTT 
DKSPFVIYD MNSLMMGED KIKFKHITP 
LQEQSKEVA IRIFQGCQF RSVEAVQEI 
TEYAKSIPG FVNLDLNDQ VTLLKYGVH 
EIIYTMLAS LMNKDGVLI SEGQGFMTR 
EFLKSLRKP FGDFMEPKF EFAVKFNAL 
ELDDSDLAI FIAVIILSG DRPGLLNVK 
PIEDIQDNL LQALELQLK LNHPESSQL 
FAKLLQKMT DLRQIVTEH VQLLQVIKK 
TETDMSLHP LLQEIYKDL Y

Binding hormones

    Anatomical structures with this receptor

    • adipose_tissue

      Induced phenotypes

      • regulation of fat cell differentiation
        • PPARγ expression is observed in adipose tissue in rodents. Its expression is induced early in differentiation of 3T3-L1 preadipocytes into adipocytes, and its overexpression in fibroblasts induces them to differentiate into adipocytes. [3]

    • spleen

    • heart

      Induced phenotypes

      • regulation of glucose homeostasis
        • PPAR-gamma is expressed in the heart, one tissue where most of the insulin-stimulated glucose uptake occurs. [4]

    • placenta

    • lung

    • ovary

    • fat_cell

      Induced phenotypes

      • regulation of glucose homeostasis
        • PPAR-gamma is expressed in human fat, one tissue where most of the insulin-stimulated glucose uptake occurs. [4]
    Reference