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Details for receptor: RXR-alpha

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EndoNet ID: ENR00696

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Synonyms

  • NR2B1
  • RXR-alpha
  • retinoid X receptor alpha
  • retinoic acid receptor alpha

General information

  • Expressed in lung. [1]
  • A large number of physiological processes in the adult liver are regulated by nuclear receptors that require heterodimerization with retinoid X receptors. The control of many metabolic pathways in the liver is mediated by RXR heterodimerization with PPARalpha, CARbeta, PXR, LXR, and FXR. [2]
  • The retinoid X receptor (RXR) is a nuclear receptor that functions as a ligand-activated transcription factor. [3]
  • The nuclear receptor PPARgamma/RXRalpha heterodimer regulates glucose and lipid homeostasis and is the target for the antidiabetic drugs GI262570 and the thiazolidinediones (TZDs). [4]

Links to other resources

UniProt P19793
Ensembl ENST00000356384

Subunit information

Sequence 
MDTKHFLPL DFSTQVNSS LTSPTGRGS 
MAAPSLHPS LGPGIGSPG QLHSPISTL 
SSPINGMGP PFSVISSPM GPHSMSVPT 
TPTLGFSTG SPQLSSPMN PVSSSEDIK 
PPLGLNGVL KVPAHPSGN MASFTKHIC 
AICGDRSSG KHYGVYSCE GCKGFFKRT 
VRKDLTYTC RDNKDCLID KRQRNRCQY 
CRYQKCLAM GMKREAVQE ERQRGKDRN 
ENEVESTSS ANEDMPVER ILEAELAVE 
PKTETYVEA NMGLNPSSP NDPVTNICQ 
AADKQLFTL VEWAKRIPH FSELPLDDQ 
VILLRAGWN ELLIASFSH RSIAVKDGI 
LLATGLHVH RNSAHSAGV GAIFDRVLT 
ELVSKMRDM QMDKTELGC LRAIVLFNP 
DSKGLSNPA EVEALREKV YASLEAYCK 
HKYPEQPGR FAKLLLRLP ALRSIGLKC 
LEHLFFFKL IGDTPIDTF LMEMLEAPH 
QMT

Binding hormones

  • IGFBP-3

Anatomical structures with this receptor

  • brain

  • hepatocyte

  • lung

  • kidney

  • heart

  • macrophage

Reference