Status
Please wait ...

Details for receptor: FGFR-1

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00698

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • bFGF-R
  • CD331 antigen
  • FGFR-1
  • fibroblast growth factor receptor 1
  • FGFR1

General information

  • FGFR-1 regulates negatively endothelial cell function by altering the balance of modulatory cytokines. [1]
  • FGFR1 is expressed by hepatic cell progenitors and adult nonparenchymal cells, but not in mature hepatocytes. [2]

Links to other resources

UniProt P11362
Ensembl ENST00000447712

Subunit information

basic fibroblast growth factor receptor

Sequence 
RPSPTLPEQ AQPWGAPVE VESFLVHPG 
DLLQLRCRL RDDVQSINW LRDGVQLAE 
SNRTRITGE EVEVQDSVP ADSGLYACV 
TSSPSGSDT TYFSVNVSD ALPSSEDDD 
DDDDSSSEE KETDNTKPN RMPVAPYWT 
SPEKMEKKL HAVPAAKTV KFKCPSSGT 
PNPTLRWLK NGKEFKPDH RIGGYKVRY 
ATWSIIMDS VVPSDKGNY TCIVENEYG 
SINHTYQLD VVERSPHRP ILQAGLPAN 
KTVALGSNV EFMCKVYSD PQPHIQWLK 
HIEVNGSKI GPDNLPYVQ ILKTAGVNT 
TDKEMEVLH LRNVSFEDA GEYTCLAGN 
SIGLSHHSA WLTVLEALE ERPAVMTSP 
LYLEIIIYC TGAFLISCM VGSVIVYKM 
KSGTKKSDF HSQMAVHKL AKSIPLRRQ 
VTVSADSSA SMNSGVLLV RPSRLSSSG 
TPMLAGVSE YELPEDPRW ELPRDRLVL 
GKPLGEGCF GQVVLAEAI GLDKDKPNR 
VTKVAVKML KSDATEKDL SDLISEMEM 
MKMIGKHKN IINLLGACT QDGPLYVIV 
EYASKGNLR EYLQARRPP GLEYCYNPS 
HNPEEQLSS KDLVSCAYQ VARGMEYLA 
SKKCIHRDL AARNVLVTE DNVMKIADF 
GLARDIHHI DYYKKTTNG RLPVKWMAP 
EALFDRIYT HQSDVWSFG VLLWEIFTL 
GGSPYPGVP VEELFKLLK EGHRMDKPS 
NCTNELYMM MRDCWHAVP SQRPTFKQL 
VEDLDRIVA LTSNQEYLD LSMPLDQYS 
PSFPDTRSS TCSSGEDSV FSHEPLPEE 
PCLPRHPAQ LANGGLKRR
UniProt P11362-1

Binding hormones

  • FGF-1 isoform 1
  • FGF-9
    • The FGFs 9, 16, and 20 subfamily members activated FGFR 1-3c isoforms and FGFR4 with high activity. [3]
  • FGF-16
    • The FGFs 9, 16, and 20 subfamily members activated FGFR 1-3c isoforms and FGFR4 with high activity. [3]
  • FGF-20
    • The FGFs 9, 16, and 20 subfamily members activated FGFR 1-3c isoforms and FGFR4 with high activity. [3]
  • FGF-21
    • The endocrine fibroblast growth factor 21 (FGF21) requires both fibroblast growth factor receptor 1c (FGFR1c) and β-Klotho for signaling. [4]
  • FGF-23
    • The COOH terminus of FGF23 forms a trimeric complex with αKlotho and the c isoforms of FGFR 1, 3, and 4. [5]
  • FGF-5
    • FGF-5 can bind and induce autophosphorylation of human FGF receptors (FGFR) 1 and 2. [6]

Anatomical structures with this receptor

  • chondrocyte

  • brain

    Induced phenotypes

    • Kallmann syndrome 2
      • Mutations in FGFR1 or FGF8, encoding fibroblast growth factor receptor-1 and fibroblast growth factor-8, respectively, underlie an autosomal dominant form Kallmann syndrome 2 with incomplete penetrance. [7]
    • olfactory bulb morphogenesis
      • FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. [8]
      • A striking defect caused by loss of Fgfr1 in the telencephalon is a failure of normal olfactory bulb (OB) formation. [8]

  • adrenal_cortex

  • cardiac_muscle

    Induced phenotypes

    • regulation of cell proliferation
      • We can conclude that FGFR1c and FGFR2c are the only FGFRs functionally required in the developing myocardium at this stage of development. [9]
    • Sectioning of these hearts revealed that FGFR1 was expressed in the myocardium. [9]
Reference