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Details for receptor: FGFR-3

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EndoNet ID: ENR00699

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For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • CD333 antigen
  • FGFR-3
  • fibroblast growth factor receptor 3
  • FGFR3

General information

  • FGFR-3 plays an important role in the initial stages of oral cancer progression. [1]

Links to other resources

UniProt P22607
Ensembl ENST00000440486

Subunit information

fibroblast growth factor receptor 3

Sequence 
ESLGTEQRV VGRAAEVPG PEPGQQEQL 
VFGSGDAVE LSCPPPGGG PMGPTVWVK 
DGTGLVPSE RVLVGPQRL QVLNASHED 
SGAYSCRQR LTQRVLCHF SVRVTDAPS 
SGDDEDGED EAEDTGVDT GAPYWTRPE 
RMDKKLLAV PAANTVRFR CPAAGNPTP 
SISWLKNGR EFRGEHRIG GIKLRHQQW 
SLVMESVVP SDRGNYTCV VENKFGSIR 
QTYTLDVLE RSPHRPILQ AGLPANQTA 
VLGSDVEFH CKVYSDAQP HIQWLKHVE 
VNGSKVGPD GTPYVTVLK TAGANTTDK 
ELEVLSLHN VTFEDAGEY TCLAGNSIG 
FSHHSAWLV VLPAEEELV EADEAGSVY 
AGILSYGVG FFLFILVVA AVTLCRLRS 
PPKKGLGSP TVHKISRFP LKRQVSLES 
NASMSSNTP LVRIARLSS GEGPTLANV 
SELELPADP KWELSRARL TLGKPLGEG 
CFGQVVMAE AIGIDKDRA AKPVTVAVK 
MLKDDATDK DLSDLVSEM EMMKMIGKH 
KNIINLLGA CTQGGPLYV LVEYAAKGN 
LREFLRARR PPGLDYSFD TCKPPEEQL 
TFKDLVSCA YQVARGMEY LASQKCIHR 
DLAARNVLV TEDNVMKIA DFGLARDVH 
NLDYYKKTT NGRLPVKWM APEALFDRV 
YTHQSDVWS FGVLLWEIF TLGGSPYPG 
IPVEELFKL LKEGHRMDK PANCTHDLY 
MIMRECWHA APSQRPTFK QLVEDLDRV 
LTVTSTDEY LDLSAPFEQ YSPGGQDTP 
SSSSSGDDS VFAHDLLPP APPSSGGSR 
T
UniProt P22607-1

Binding hormones

  • FGF-1 isoform 1
  • FGF-16
    • The FGFs 9, 16, and 20 subfamily members activated FGFR 1-3c isoforms and FGFR4 with high activity. [2]
  • FGF-20
  • FGF-9
  • FGF-23
    • The COOH terminus of FGF23 forms a trimeric complex with αKlotho and the c isoforms of FGFR 1, 3, and 4. [3]

Anatomical structures with this receptor

  • chondrocyte

    Induced phenotypes

    • endochondral ossification
      • Fibroblast growth factor receptor (FGFR) 3 palys an essential role in the development and maintenance of bones. [4]
Reference