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Details for receptor: TNFRSF25

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EndoNet ID: ENR00701

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Synonyms

  • death receptor 3
  • TNFRSF25
  • TNFRSF12
  • TNF receptor superfamily member 25
  • DDR3
  • LARD
  • APO-3
  • WSL-1
  • WSL1
  • APO3
  • apoptosis inducing receptor
  • apoptosis-mediating receptor
  • death domain receptor 3
  • death receptor beta
  • translocating chain association membrane protein
  • TRAMP
  • TNF receptor superfamily member 12
  • AIR
  • DR3
  • WSL-LR
  • lymphocyte associated receptor of death
  • Protein WSL-1
  • Protein WSL
  • Lymphocyte-associated receptor of death
  • Apoptosis-mediating receptor TRAMP
  • Apoptosis-mediating receptor DR3
  • Apoptosis-inducing receptor AIR
  • Tumor necrosis factor receptor superfamily member 25

General information

  • Also exists in soluble form.
  • LARD (lymphocyte associated receptor of death) has a death domain and can initiate apoptosis. Alternative pre-mRNA splicing generates at least 11 isoforms of LARD, providing a range of functional outcomes that may help shape the immune response. [1]
  • Isoform 1, isoform 2, isoform 9, isoform 11: Cell membrane; single-pass type I membrane protein. Isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 10, isoform 12: Secreted protein. [2]

Links to other resources

UniProt Q93038
Ensembl ENST00000453341

Binding hormones

  • TNFSF15

Anatomical structures with this receptor

  • thymocyte

    Induced phenotypes

    • positive regulation of thymocyte apoptosis
      • TNFRSF25 might be involved in negative thymic selection. [1]
    • TNFRSF25 expression is restricted predominantly to lymphoid tissues, thymus. [1]

  • lymphocyte

    Induced phenotypes

    • positive regulation of lymphocyte apoptosis
      • The potential importance of TNFRSF25 in lymphocyte apoptosis is reflected by its restricted pattern of expression, predominantly on lymphocytes. [1]
    • TNFRSF25 is expressed in roughly equal amounts in B cells and CD4+ or CD8+ T cells, it is not expressed in macrophages. [1]

  • thymus

    Induced phenotypes

    • positive regulation of thymocyte apoptosis
      • TNFRS25 might be involved in negative thymic selection. [1]
    • TNFRSF25 expression is restricted predominantly to lymphoid tissues, thymus. [1]

  • colon

    Induced phenotypes

    • positive regulation of lymphocyte apoptosis
      • TNFRSF25 is up-regulated by alternative splicing in response to lymphocyte activation, this means that it is ideally placed to play a role in controlling lymphocyte proliferation. [1]
      • The restricted expression of TNFRSF25 suggests that like Fas receptor it may play a role in immune development and function. [1]
      • TNFRSF25 was detected in lymphocyte-rich tissues such as the thymus, colon, intestine, and spleen. [3]
    • Very low level expression was seen on the colon cancer cell line HT-29. [1]
    • A transcript of 3.2 kb was detected in lymphocyte-rich tissues such as the colon. [3]

  • spleen

    Induced phenotypes

    • positive regulation of lymphocyte apoptosis
      • TNFRSF25 is up-regulated by alternative splicing in response to lymphocyte activation, this means that it is ideally placed to play a role in controlling lymphocyte proliferation. [1]
      • The restricted expression of TNFRSF25 suggests that like Fas receptor it may play a role in immune development and function. [1]
    • TNFRSF25 expression is restricted predominantly to lymphoid tissues, spleen. [1]

  • prostate

    Induced phenotypes

    • positive regulation of apoptosis
      • TNFRSF25 is weakly expressed in the prostate. One biological role of TNFRSF25 may be to trigger a cell-death program upon binding of its cognate ligand. [4]
      • In addition, TNFRSF25 appears to be capable of activating the transcription factor NF-κB, suggesting that, like TNFR1, this receptor may regulate distinct signaling pathways in different cellular contexts. [4]
Reference