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Details for receptor: FGFR-4

EndoNet ID: ENR00702

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Synonyms

  • FGFR-4
  • fibroblast growth factor receptor 4
  • FGFR4
  • CD334 antigen

General information

  • Of the four FGF receptors, only FGFR4 is expressed in mature hepatocytes. [1]
  • FGFR4 plays important roles in systemic lipid and glucose homeostasis. [2]

Links to other resources

UniProt P22455
Ensembl ENST00000453701

Subunit information

Sequence
LEASEEVEL EPCLAPSLE QQEQELTVA 
LGQPVRLCC GRAERGGHW YKEGSRLAP 
AGRVRGWRG RLEIASFLP EDAGRYLCL 
ARGSMIVLQ NLTLITGDS LTSSNDDED 
PKSHRDPSN RHSYPQQAP YWTHPQRME 
KKLHAVPAG NTVKFRCPA AGNPTPTIR 
WLKDGQAFH GENRIGGIR LRHQHWSLV 
MESVVPSDR GTYTCLVEN AVGSIRYNY 
LLDVLERSP HRPILQAGL PANTTAVVG 
SDVELLCKV YSDAQPHIQ WLKHIVING 
SSFGADGFP YVQVLKTAD INSSEVEVL 
YLRNVSAED AGEYTCLAG NSIGLSYQS 
AWLTVLPEE DPTWTAAAP EARYTDIIL 
YASGSLALA VLLLLAGLY RGQALHGRH 
PRPPATVQK LSRFPLARQ FSLESGSSG 
KSSSSLVRG VRLSSSGPA LLAGLVSLD 
LPLDPLWEF PRDRLVLGK PLGEGCFGQ 
VVRAEAFGM DPARPDQAS TVAVKMLKD 
NASDKDLAD LVSEMEVMK LIGRHKNII 
NLLGVCTQE GPLYVIVEC AAKGNLREF 
LRARRPPGP DLSPDGPRS SEGPLSFPV 
LVSCAYQVA RGMQYLESR KCIHRDLAA 
RNVLVTEDN VMKIADFGL ARGVHHIDY 
YKKTSNGRL PVKWMAPEA LFDRVYTHQ 
SDVWSFGIL LWEIFTLGG SPYPGIPVE 
ELFSLLREG HRMDRPPHC PPELYGLMR 
ECWHAAPSQ RPTFKQLVE ALDKVLLAV 
SEEYLDLRL TFGPYSPSG GDASSTCSS 
SDSVFSHDP LPLGSSSFP FGSGVQT

Binding hormones

  • FGF-19
  • FGF-6
  • FGF-8
  • FGF-2
  • FGF-1 isoform 1
  • FGF-9
  • FGF-18
  • FGF-17
  • FGF-23
    • The COOH terminus of FGF23 forms a trimeric complex with ╬▒Klotho and the c isoforms of FGFR 1, 3, and 4.

Anatomical structures with this receptor

  • hepatocyte

Reference