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Details for receptor: TLR6

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EndoNet ID: ENR00703

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http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • TLR6
  • toll-like receptor 6

General information

  • Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [1]
  • Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. [1]

Links to other resources

UniProt Q9Y2C9
Ensembl ENST00000440845

Subunit information

Sequence 
NEFAVDKSK RGLIHVPKD LPLKTKVLD 
MSQNYIAEL QVSDMSFLS ELTVLRLSH 
NRIQLLDLS VFKFNQDLE YLDLSHNQL 
QKISCHPIV SFRHLDLSF NDFKALPIC 
KEFGNLSQL NFLGLSAMK LQKLDLLPI 
AHLHLSYIL LDLRNYYIK ENETESLQI 
LNAKTLHLV FHPTSLFAI QVNISVNTL 
GCLQLTNIK LNDDNCQVF IKFLSELTR 
GPTLLNFTL NHIETTWKC LVRVFQFLW 
PKPVEYLNI YNLTIIESI REEDFTYSK 
TTLKALTIE HITNQVFLF SQTALYTVF 
SEMNIMMLT ISDTPFIHM LCPHAPSTF 
KFLNFTQNV FTDSIFEKC STLVKLETL 
ILQKNGLKD LFKVGLMTK DMPSLEILD 
VSWNSLESG RHKENCTWV ESIVVLNLS 
SNMLTDSVF RCLPPRIKV LDLHSNKIK 
SVPKQVVKL EALQELNVA FNSLTDLPG 
CGSFSSLSV LIIDHNSVS HPSADFFQS 
CQKMRSIKA GDNPFQCTC ELREFVKNI 
DQVSSEVLE GWPDSYKCD YPESYRGSP 
LKDFHMSEL SCNITLLIV TIGATMLVL 
AVTVTSLCI YLDLPWYLR MVCQWTQTR 
RRARNIPLE ELQRNLQFH AFISYSEHD 
SAWVKSELV PYLEKEDIQ ICLHERNFV 
PGKSIVENI INCIEKSYK SIFVLSPNF 
VQSEWCHYE LYFAHHNLF HEGSNNLIL 
ILLEPIPQN SIPNKYHKL KALMTQRTY 
LQWPKEKSK RGLFWANIR AAFNMKLTL 
VTENNDVKS

Binding hormones

    Anatomical structures with this receptor

    • monocyte

    • dendritic_cell_in_lymphoid_tissues

    • vaginal_mucosa

    • cervical_canal_of_uterus

    • cholangiocyte

    • epithelial_cell_with_microvilli

    • bronchial_epithelial_cell

    • macrophage

      Influences

      • positive IL-1 beta
        • IL-1β is first synthesized as biologically-inactive precursor (pro-IL-1β) in response to Toll-like receptor (TLR) agonists in macrophages. [2]
    Reference