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Details for receptor: IL6ST

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EndoNet ID: ENR00705

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Synonyms

  • IL6ST
  • oncostatin M receptor
  • CD130 antigen
  • membrane glykoprotein 130
  • gp130
  • CDw130
  • IL-6R-beta
  • interleukin 6 signal transducer

General information

  • IL-11R alpha and gp130 are expressed in both luminal and glandular epithelium. [1]
  • Found in all the tissues and cell lines examined, expression not restricted to IL-6 responsive cells. [2]
  • Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. [2]
  • Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. [2]

Links to other resources

UniProt P40189
Ensembl ENST00000423954

Subunit information

membrane form

Sequence 
ELLDPCGYI SPESPVVQL HSNFTAVCV 
LKEKCMDYF HVNANYIVW KTNHFTIPK 
EQYTIINRT ASSVTFTDI ASLNIQLTC 
NILTFGQLE QNVYGITII SGLPPEKPK 
NLSCIVNEG KKMRCEWDG GRETHLETN 
FTLKSEWAT HKFADCKAK RDTPTSCTV 
DYSTVYFVN IEVWVEAEN ALGKVTSDH 
INFDPVYKV KPNPPHNLS VINSEELSS 
ILKLTWTNP SIKSVIILK YNIQYRTKD 
ASTWSQIPP EDTASTRSS FTVQDLKPF 
TEYVFRIRC MKEDGKGYW SDWSEEASG 
ITYEDRPSK APSFWYKID PSHTQGYRT 
VQLVWKTLP PFEANGKIL DYEVTLTRW 
KSHLQNYTV NATKLTVNL TNDRYLATL 
TVRNLVGKS DAAVLTIPA CDFQATHPV 
MDLKAFPKD NMLWVEWTT PRESVKKYI 
LEWCVLSDK APCITDWQQ EDGTVHRTY 
LRGNLAESK CYLITVTPV YADGPGSPE 
SIKAYLKQA PPSKGPTVR TKKVGKNEA 
VLEWDQLPV DVQNGFIRN YTIFYRTII 
GNETAVNVD SSHTEYTLS SLTSDTLYM 
VRMAAYTDE GGKDGPEFT FTTPKFAQG 
EIEAIVVPV CLAFLLTTL LGVLFCFNK 
RDLIKKHIW PNVPDPSKS HIAQWSPHT 
PPRHNFNSK DQMYSDGNF TDVSVVEIE 
ANDKKPFPE DLKSLDLFK KEKINTEGH 
SSGIGGSSC MSSSRPSIS SSDENESSQ 
NTSSTVQYS TVVHSGYRH QVPSVQVFS 
RSESTQPLL DSEERPEDL QLVDHVDGG 
DGILPRQQY FKQNCSQHE SSPDISHFE 
RSKQVSSVN EEDFVRLKQ QISDHISQS 
CGSGQMKMF QEVSAADAF GPGTEGQVE 
RFETVGMEA ATDEGMPKS YLPQTVRQG 
GYMPQ
UniProt P40189-1

Binding hormones

  • cardiotrophin 1
    • Binds to and activates the ILST/gp130 receptor. [2]
  • CLC
    • Heterodimeric CLF-1/CLC binds to CNTF R alpha, thereby activating signaling through gp130 and LIF R beta, the signaling subunits of the tripartite CNTF R complex. [3]

Anatomical structures with this receptor

  • cell_of_endometrium_of_uterus

Reference