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Details for receptor: ErbB3

EndoNet ID: ENR00708

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Synonyms

  • c-erbB3
  • HER3
  • ErbB3

General information

  • Binds and is activated by neuregulins and NTAK. [1]
  • Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5. [1]
  • Activation of ErbB receptors is important for the regulation of cell proliferation, differentiation, and survival. Binding of specific ligand to one of the ErbB receptors triggers the formation of specific receptor homo- and heterodimers, with ErbB2 beeing the preferred signaling partner. [2]

Links to other resources

UniProt P21860
Ensembl ENST00000450146

Subunit information

Sequence
EVGNSQAVC PGTLNGLSV TGDAENQYQ 
TLYKLYERC EVVMGNLEI VLTGHNADL 
SFLQWIREV TGYVLVAMN EFSTLPLPN 
LRVVRGTQV YDGKFAIFV MLNYNTNSS 
HALRQLRLT QLTEILSGG VYIEKNDKL 
CHMDTIDWR DIVRDRDAE IVVKDNGRS 
CPPCHEVCK GRCWGPGSE DCQTLTKTI 
CAPQCNGHC FGPNPNQCC HDECAGGCS 
GPQDTDCFA CRHFNDSGA CVPRCPQPL 
VYNKLTFQL EPNPHTKYQ YGGVCVASC 
PHNFVVDQT SCVRACPPD KMEVDKNGL 
KMCEPCGGL CPKACEGTG SGSRFQTVD 
SSNIDGFVN CTKILGNLD FLITGLNGD 
PWHKIPALD PEKLNVFRT VREITGYLN 
IQSWPPHMH NFSVFSNLT TIGGRSLYN 
RGFSLLIMK NLNVTSLGF RSLKEISAG 
RIYISANRQ LCYHHSLNW TKVLRGPTE 
ERLDIKHNR PRRDCVAEG KVCDPLCSS 
GGCWGPGPG QCLSCRNYS RGGVCVTHC 
NFLNGEPRE FAHEAECFS CHPECQPME 
GTATCNGSG SDTCAQCAH FRDGPHCVS 
SCPHGVLGA KGPIYKYPD VQNECRPCH 
ENCTQGCKG PELQDCLGQ TLVLIGKTH 
LTMALTVIA GLVVIFMML GGTFLYWRG 
RRIQNKRAM RRYLERGES IEPLDPSEK 
ANKVLARIF KETELRKLK VLGSGVFGT 
VHKGVWIPE GESIKIPVC IKVIEDKSG 
RQSFQAVTD HMLAIGSLD HAHIVRLLG 
LCPGSSLQL VTQYLPLGS LLDHVRQHR 
GALGPQLLL NWGVQIAKG MYYLEEHGM 
VHRNLAARN VLLKSPSQV QVADFGVAD 
LLPPDDKQL LYSEAKTPI KWMALESIH 
FGKYTHQSD VWSYGVTVW ELMTFGAEP 
YAGLRLAEV PDLLEKGER LAQPQICTI 
DVYMVMVKC WMIDENIRP TFKELANEF 
TRMARDPPR YLVIKRESG PGIAPGPEP 
HGLTNKKLE EVELEPELD LDLDLEAEE 
DNLATTTLG SALSLPVGT LNRPRGSQS 
LLSPSSGYM PMNQGNLGE SCQESAVSG 
SSERCPRPV SLHPMPRGC LASESSEGH 
VTGSEAELQ EKVSMCRSR SRSRSPRPR 
GDSAYHSQR HSLLTPVTP LSPPGLEEE 
DVNGYVMPD THLKGTPSS REGTLSSVG 
LSSVLGTEE EDEDEEYEY MNRRRRHSP 
PHPPRPSSL EELGYEYMD VGSDLSASL 
GSTQSCPLH PVPIMPTAG TTPDEDYEY 
MNRQRDGGG PGGDYAAMG ACPASEQGY 
EEMRAFQGP GHQAPHVHY ARLKTLRSL 
EATDSAFDN PDYWHSRLF PKANAQRT

Binding hormones

  • NRG-1
  • neuregulin-2
    • NRG-2 is a ligand for ERBB3 and ERBB4 tyrosine kinase receptors. [1]
  • NRG1-beta1
  • neuregulin 1 isoform SMDF
  • NRG1-beta3

Anatomical structures with this receptor

    Reference