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Details for receptor: Interleukin-22 receptor subunit alpha-1

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EndoNet ID: ENR00710

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Synonyms

  • Interleukin-22 receptor subunit alpha-1
  • Interleukin 22 receptor
  • CRF2-9

General information

  • Component of the receptor for IL20, IL22 and IL24. [1]

Links to other resources

UniProt Q8N6P7

Subunit information

unprocessed precursor

  • With IL-10R2 (IL10RB) IL-22R1 acts as the receptor for IL22.
Sequence 
MRTLLTILT VGSLAAHAP EDPSDLLQH 
VKFQSSNFE NILTWDSGP EGTPDTVYS 
IEYKTYGER DWVAKKGCQ RITRKSCNL 
TVETGNLTE LYYARVTAV SAGGRSATK 
MTDRFSSLQ HTTLKPPDV TCISKVRSI 
QMIVHPTPT PIRAGDGHR LTLEDIFHD 
LFYHLELQV NRTYQMHLG GKQREYEFF 
GLTPDTEFL GTIMICVPT WAKESAPYM 
CRVKTLPDR TWTYSFSGA FLFSMGFLV 
AVLCYLSYR YVTKPPAPP NSLNVQRVL 
TFQPLRFIQ EHVLIPVFD LSGPSSLAQ 
PVQYSQIRV SGPREPAGA PQRHSLSEI 
TYLGQPDIS ILQPSNVPP PQILSPLSY 
APNAAPEVG PPSYAPQVT PEAQFPFYA 
PQAISKVQP SSYAPQATP DSWPPSYGV 
CMEGSGKDS PTGTLSSPK HLRPKGQLQ 
KEPPAGSCM LGGLSLQEV TSLAMEESQ 
EAKSLHQPL GICTDRTSD PNVLHSGEE 
GTPQYLKGQ LPLLSSVQI EGHPMSLPL 
QPPSRPCSP SDQGPSPWG LLESLVCPK 
DEAKSPAPE TSDLEQPTE LDSLFRGLA 
LTVQWES

Binding hormones

  • IL-22
    • We report here the identification of a functional IL-22 receptor complex that consists of two receptor chains, the orphan IL22RA1 and IL-10R2 [2]
  • IL-20
    • IL-20 also signals through the IL-22RA1/IL-20R2 (type II) receptor complex. [3]

Anatomical structures with this receptor

  • cell:plasma_cell

    • To identity potential cellular targets expressing IL-22RA2, in situ hybridization analysis was performed on various human tissues. Among tissues screened, strong signals were observed in the mononuclear cells of inflammatory infiltration sites, plasma cells, and a subset of epithelial cells [4]

  • placenta

    • issues that gave positive signals included placenta, skin, inflamed appendix, lung, gastrointestinal tract, lymph node, thymus, and spleen [4]

  • lymph_node

    • issues that gave positive signals included placenta, skin, inflamed appendix, lung, gastrointestinal tract, lymph node, thymus, and spleen [4]

  • skin

    • issues that gave positive signals included placenta, skin, inflamed appendix, lung, gastrointestinal tract, lymph node, thymus, and spleen [4]

  • epithelial_cell

    • issues that gave positive signals included placenta, skin, inflamed appendix, lung, gastrointestinal tract, lymph node, thymus, and spleen [4]

  • thymus

    • issues that gave positive signals included placenta, skin, inflamed appendix, lung, gastrointestinal tract, lymph node, thymus, and spleen [4]

  • spleen

    • issues that gave positive signals included placenta, skin, inflamed appendix, lung, gastrointestinal tract, lymph node, thymus, and spleen [4]
Reference