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Details for receptor: PTC1

EndoNet ID: ENR00712

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  • PTC1
  • protein patched homolog 1
  • PTC
  • PTCH
  • PTCH1
  • patched 1

General information

  • In the absence of SHH, PTC represses the constitutive signaling activity of SMO. [1]
  • Receptor for SHH, IHH and DHH.
  • The Ptc tumour suppressor functions normally as a transmembrane molecular transporter, which acts indirectly to inhibit Smo activity, possibly through changes in distribution or concentration of a small molecule. [2]
  • Patched induces apoptotic cell death unless its ligand Shh is present to block the signal. [3]
  • Mutations affecting the transmembrane proteins Patched (Ptc) or Smoothened (Smo) that trigger ligand-independent activity of the Hedgehog (Hh) signalling pathway are associated with human tumours such as basal cell carcinoma (BCC) and medulloblastoma. [2]

Links to other resources

UniProt Q13635
Ensembl ENST00000450369

Binding hormones

  • SHH
  • IHH
    • Indian hedgehog (Ihh) has two signaling receptors: patched (Ptc) and smoothened (Smo). [4]
  • DHH
    • Patched (Ptc/Ptch) is a twelve-pass transmembrane sterol-sensing domain protein that binds alle three mammalian Hh ligands [5]

Anatomical structures with this receptor

  • brain

  • lung

  • heart

  • kidney

  • pancreas

  • skeleton_muscle

  • placenta

  • mesenchyme_cell

    Induced phenotypes

    • lung development
      • The interaction between Shh and Ptc is required for lung bud formation. [6]
    • Its receptor Patched-1 (Ptc) is located in the mesenchymal cells. [6]