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Details for receptor: IL-1RII

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EndoNet ID: ENR00715

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Synonyms

  • IL-1RII
  • IL-1R-beta
  • antigen CD121b
  • antigen CDw121b
  • interleukin-1 receptor, type II

General information

  • Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1ra). [1]
  • Isolated human osteoclasts(OCs) and primary bone marrow-derived OC-like cells expressed both the signaling (IL-1RI) and decoy (IL-1RII) IL-1 receptors. [2]

Links to other resources

UniProt P27930
Ensembl ENST00000457817

Subunit information

Sequence 
FTLQPAAHT GAARSCRFR GRHYKREFR 
LEGEPVALR CPQVPYWLW ASVSPRINL 
TWHKNDSAR TVPGEEETR MWAQDGALW 
LLPALQEDS GTYVCTTRN ASYCDKMSI 
ELRVFENTD AFLPFISYP QILTLSTSG 
VLVCPDLSE FTRDKTDVK IQWYKDSLL 
LDKDNEKFL SVRGTTHLL VHDVALEDA 
GYYRCVLTF AHEGQQYNI TRSIELRIK 
KKKEETIPV IISPLKTIS ASLGSRLTI 
PCKVFLGTG TPLTTMLWW TANDTHIES 
AYPGGRVTE GPRQEYSEN NENYIEVPL 
IFDPVTRED LHMDFKCVV HNTLSFQTL 
RTTVKEASS TFSWGIVLA PLSLAFLVL 
GGIWMHRRC KHRTGKADG LTVLWPHHQ 
DFQSYPK

Binding hormones

  • IL-1 alpha
  • IL-1 beta
  • IL-1RA

Anatomical structures with this receptor

  • osteoclast

  • dendritic_cell_in_lymphoid_tissues_follicular

  • macrophage

    Influences

    • positive PAF
      • IL-1 induce PAF synthesis by monocyte/macrophages. [3]

  • monocyte

    Influences

    • positive PAF
      • IL-1 induce PAF synthesis by monocyte/macrophages. [3]

  • lipocyte_of_liver

    Influences

    • positive RANTES
      • Hepatic stellate cells secrete RANTES after stimulation with TNF-alpha, IL-1beta, and CD40L in an inhibitor-kappaB (I kappa B)kinase (IKK)2/NF kappaB- and JNK-dependent manner. [4]
Reference