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Details for receptor: ErbB2

EndoNet ID: ENR00720

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Synonyms

  • p185erbb2
  • c-erbB2
  • ErbB2
  • HER2

General information

  • Essential component of a neuregulin-receptor complex, althought neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin. [1]
  • Activation of ErbB receptors is important for the regulation of cell proliferation, differentiation, and survival. Binding of specific ligand to one of the ErbB receptors triggers the formation of specific receptor homo- and heterodimers, with ErbB2 beeing the preferred signaling partner. [2]

Links to other resources

UniProt P04626
Ensembl ENST00000445658

Subunit information

Sequence
TQVCTGTDM KLRLPASPE THLDMLRHL 
YQGCQVVQG NLELTYLPT NASLSFLQD 
IQEVQGYVL IAHNQVRQV PLQRLRIVR 
GTQLFEDNY ALAVLDNGD PLNNTTPVT 
GASPGGLRE LQLRSLTEI LKGGVLIQR 
NPQLCYQDT ILWKDIFHK NNQLALTLI 
DTNRSRACH PCSPMCKGS RCWGESSED 
CQSLTRTVC AGGCARCKG PLPTDCCHE 
QCAAGCTGP KHSDCLACL HFNHSGICE 
LHCPALVTY NTDTFESMP NPEGRYTFG 
ASCVTACPY NYLSTDVGS CTLVCPLHN 
QEVTAEDGT QRCEKCSKP CARVCYGLG 
MEHLREVRA VTSANIQEF AGCKKIFGS 
LAFLPESFD GDPASNTAP LQPEQLQVF 
ETLEEITGY LYISAWPDS LPDLSVFQN 
LQVIRGRIL HNGAYSLTL QGLGISWLG 
LRSLRELGS GLALIHHNT HLCFVHTVP 
WDQLFRNPH QALLHTANR PEDECVGEG 
LACHQLCAR GHCWGPGPT QCVNCSQFL 
RGQECVEEC RVLQGLPRE YVNARHCLP 
CHPECQPQN GSVTCFGPE ADQCVACAH 
YKDPPFCVA RCPSGVKPD LSYMPIWKF 
PDEEGACQP CPINCTHSC VDLDDKGCP 
AEQRASPLT SIISAVVGI LLVVVLGVV 
FGILIKRRQ QKIRKYTMR RLLQETELV 
EPLTPSGAM PNQAQMRIL KETELRKVK 
VLGSGAFGT VYKGIWIPD GENVKIPVA 
IKVLRENTS PKANKEILD EAYVMAGVG 
SPYVSRLLG ICLTSTVQL VTQLMPYGC 
LLDHVRENR GRLGSQDLL NWCMQIAKG 
MSYLEDVRL VHRDLAARN VLVKSPNHV 
KITDFGLAR LLDIDETEY HADGGKVPI 
KWMALESIL RRRFTHQSD VWSYGVTVW 
ELMTFGAKP YDGIPAREI PDLLEKGER 
LPQPPICTI DVYMIMVKC WMIDSECRP 
RFRELVSEF SRMARDPQR FVVIQNEDL 
GPASPLDST FYRSLLEDD DMGDLVDAE 
EYLVPQQGF FCPDPAPGA GGMVHHRHR 
SSSTRSGGG DLTLGLEPS EEEAPRSPL 
APSEGAGSD VFDGDLGMG AAKGLQSLP 
THDPSPLQR YSEDPTVPL PSETDGYVA 
PLTCSPQPE YVNQPDVRP QPPSPREGP 
LPAARPAGA TLERPKTLS PGKNGVVKD 
VFAFGGAVE NPEYLTPQG GAAPQPHPP 
PAFSPAFDN LYYWDQDPP ERGAPPSTF 
KGTPTAENP EYLGLDVPV

Binding hormones

  • NRG-1
  • neuregulin 1 isoform GGF2
  • NRG1-beta3

Anatomical structures with this receptor

    Reference