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Details for receptor: ACTRIIA

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EndoNet ID: ENR00724

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Synonyms

  • activin receptor type 2
  • ACTR-II
  • ACTRIIA

General information

  • Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. [1]
  • ALK4 and ActRIIA are the primary receptors for Nodal signaling during early development. [2]

Links to other resources

UniProt P27037
Ensembl ENST00000404590

Subunit information

Sequence 
AILGRSETQ ECLFFNANW EKDRTNQTG 
VEPCYGDKD KRRHCFATW KNISGSIEI 
VKQGCWLDD INCYDRTDC VEKKDSPEV 
YFCCCEGNM CNEKFSYFP EMEVTQPTS 
NPVTPKPPY YNILLYSLV PLMLIAGIV 
ICAFWVYRH HKMAYPPVL VPTQDPGPP 
PPSPLLGLK PLQLLEVKA RGRFGCVWK 
AQLLNEYVA VKIFPIQDK QSWQNEYEV 
YSLPGMKHE NILQFIGAE KRGTSVDVD 
LWLITAFHE KGSLSDFLK ANVVSWNEL 
CHIAETMAR GLAYLHEDI PGLKDGHKP 
AISHRDIKS KNVLLKNNL TACIADFGL 
ALKFEAGKS AGDTHGQVG TRRYMAPEV 
LEGAINFQR DAFLRIDMY AMGLVLWEL 
ASRCTAADG PVDEYMLPF EEEIGQHPS 
LEDMQEVVV HKKKRPVLR DYWQKHAGM 
AMLCETIEE CWDHDAEAR LSAGCVGER 
ITQMQRLTN IITTEDIVT VVTMVTNVD 
FPPKESSL

Binding hormones

  • inhibin B
  • BMP-11
  • inhibin A
  • activin A
  • NODAL

Anatomical structures with this receptor

  • basophil_gonadotroph_cell_of_anterior_pituitary_FSH

    Influences

    • positive FSH
      • While FSH secretion in LbetaT2 cells was stimulated, in a dose-dependent manner, by activin alone, and was unaffected by GnRH alone, there was a synergistic effect between the two treatments. [3]
      • FSH produced in LbetaT2 cells under activin/GnRH stimulation is constitutively secreted via a granin-independent pathway. [3]
    • positive LH
      • Activin had a stimulatory effect on LH secretion, although this response was not dose dependent. [3]
      • Combined activin+GnRH induced a further increase over individual treatment levels, which appeared to be additive rather than synergistic. [3]

  • cell_of_endometrium_of_uterus

    Induced phenotypes

    • cell differentiation
      • Human endometrium expresses activin A recpetor type I and type II. Thereby, it is a target for activin A, which stimulates stromal cell differentiation along with the expression and secretion of markers of endometrial receptivity. [4]
Reference