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Details for receptor: H3

EndoNet ID: ENR00725

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  • H3
  • histamine H3 receptor
  • G-protein coupled receptor 97
  • HH3R

General information

  • Expression in histaminergic neurons, eosinophils, dendritic cells, monocytes, low expression in peripheral tissues. [1]
  • HR3 has initially been identifi ed in the central and peripheral nervous system as presynaptic receptors controlling the release of histamine and other neurotransmitters (dopamine, serotonine, noradrenaline, gamma-aminobutyric acid and acetylocholine). [1]
  • Activated intracellular signals: enhanced Ca+2, MAP kinase, inhibition of cAMP. [1]

Links to other resources

UniProt Q9Y5N1
Ensembl ENST00000456442

Binding hormones

  • histamine

Anatomical structures with this receptor

  • monocyte

  • dendritic_cell_in_lymphoid_tissues

  • eosinophil_granulocyte