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Details for receptor: M4

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EndoNet ID: ENR00728

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http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • M4
  • muscarinic acetylcholine receptor M4
  • CHRM4

General information

  • M2, M4 and M5 muscarinic receptor subtypes bound in human corneal epithelium and endothelium. No binding was found for antibodies to M1 and M3 muscarinic receptor subtypes. [1]

Links to other resources

UniProt P08173
Ensembl ENST00000433765

Subunit information

Sequence 
MANFTPVNG SSGNQSVRL VTSSSHNRY 
ETVEMVFIA TVTGSLSLV TVVGNILVM 
LSIKVNRQL QTVNNYFLF SLACADLII 
GAFSMNLYT VYIIKGYWP LGAVVCDLW 
LALDYVVSN ASVMNLLII SFDRYFCVT 
KPLTYPARR TTKMAGLMI AAAWVLSFV 
LWAPAILFW QFVVGKRTV PDNQCFIQF 
LSNPAVTFG TAIAAFYLP VVIMTVLYI 
HISLASRSR VHKHRPEGP KEKKAKTLA 
FLKSPLMKQ SVKKPPPGE AAREELRNG 
KLEEAPPPA LPPPPRPVA DKDTSNESS 
SGSATQNTK ERPATELST TEATTPAMP 
APPLQPRAL NPASRWSKI QIVTKQTGN 
ECVTAIEIV PATPAGMRP AANVARKFA 
SIARNQVRK KRQMAARER KVTRTIFAI 
LLAFILTWT PYNVMVLVN TFCQSCIPD 
TVWSIGYWL CYVNSTINP ACYALCNAT 
FKKTFRHLL LCQYRNIGT AR

Binding hormones

  • acetylcholine

Anatomical structures with this receptor

  • corneal_endothelial_cell

  • adrenal_medulla

    Influences

    • positive acetylcholine
      • Muscarinic receptor stimulation was also found to enhance nicotineinduced catecholamine secretion by 1.7-fold if muscarine wasa dded 30 s before nicotine addition. [2]
Reference