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Details for receptor: EP2

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  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00729

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Synonyms

  • prostanoid EP2 receptor
  • PGE receptor, EP2 subtype
  • prostaglandin E2 receptor, EP2 subtype
  • EP2

General information

  • EP2, EP3 and EP4 subtypes were expressed in monocyte. [1]
  • EP2 binding to PGE2(prostaglandin E2) leads to cAMP signaling and cystogenesis by a mechanism that involves protection of cystic epithelial cells from apoptosis. [2]
  • Cyclical variation in endometrial EP2 and EP4 receptor mRNA expression was quantified by TaqMan quantitative RT-PCR using RNA isolated from endometrial tissue collected across the menstrual cycle. [3]

Links to other resources

UniProt P43116
Ensembl ENST00000245457

Subunit information

Sequence 
MGNASNDSQ SEDCETRQW LPPGESPAI 
SSVMFSAGV LGNLIALAL LARRWRGDV 
GCSAGRRSS LSLFHVLVT ELVFTDLLG 
TCLISPVVL ASYARNQTL VALAPESRA 
CTYFAFAMT FFSLATMLM LFAMALERY 
LSIGHPYFY QRRVSRSGG LAVLPVIYA 
VSLLFCSLP LLDYGQYVQ YCPGTWCFI 
RHGRTAYLQ LYATLLLLL IVSVLACNF 
SVILNLIRM HRRSRRSRC GPSLGSGRG 
GPGARRRGE RVSMAEETD HLILLAIMT 
ITFAVCSLP FTIFAYMNE TSSRKEKWD 
LQALRFLSI NSIIDPWVF AILRPPVLR 
LMRSVLCCR ISLRTQDAT QTSCSTQSD 
ASKQADL

Binding hormones

  • PGE2
  • PGE1

Anatomical structures with this receptor

  • placenta

  • lung

  • cell_of_endometrium_of_uterus

  • monocyte

    Influences

    • negative TNF-alpha
      • PGE1, PGE2 and cicaprost suppressed the elaboration of TNF-alpha in LPS-stimulated cells in a concentration-dependent manner. TNF-alpha generation was inhibited by 85 to 90% at the highest concentration (10 mM) of agonist tested. [4]
Reference