Status
Please wait ...

Details for receptor: EP4

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00731

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • EP4
  • prostanoid EP4 receptor
  • PGE receptor, EP4 subtype
  • prostaglandin E2 receptor, EP4 subtype

General information

  • The EP(4) receptor was detected in foetal osteoclasts, osteoblasts and osteocytes and in adult osteoclasts and osteoblasts, but not in adult osteocytes. [1]
  • EP4 receptor mRNA expression was significantly higher in late proliferative stage (P < 0.05) than in early, mid, and late secretory stage endometrium. [2]
  • High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle. [3]
  • Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. [3]

Links to other resources

UniProt P35408
Ensembl ENST00000302472

Subunit information

Sequence 
MSTPGVNSS ASLSPDRLN SPVTIPAVM 
FIFGVVGNL VAIVVLCKS RKEQKETTF 
YTLVCGLAV TDLLGTLLV SPVTIATYM 
KGQWPGGQP LCEYSTFIL LFFSLSGLS 
IICAMSVER YLAINHAYF YSHYVDKRL 
AGLTLFAVY ASNVLFCAL PNMGLGSSR 
LQYPDTWCF IDWTTNVTA HAAYSYMYA 
GFSSFLILA TVLCNVLVC GALLRMHRQ 
FMRRTSLGT EQHHAAAAA SVASRGHPA 
ASPALPRLS DFRRRRSFR RIAGAEIQM 
VILLIATSL VVLICSIPL VVRVFVNQL 
YQPSLEREV SKNPDLQAI RIASVNPIL 
DPWIYILLR KTVLSKAIE KIKCLFCRI 
GGSRRERSG QHCSDSQRT SSAMSGHSR 
SFISRELKE ISSTSQTLL PDLSLPDLS 
ENGLGGRNL LPGVPGMGL AQEDTTSLR 
TLRISETSD SSQGQDSES VLLVDEAGG 
SGRAGPAPK GSSLQVTFP SETLNLSEK 
CI

Binding hormones

  • PGE2
    • Mature human osteoclasts present 2 subtypes of EP receptors, namely EP3 and EP4, that mediate different actions of PGE2 on these cells: activation of the EP4 receptors inhibits actin ring formation and activation of the EP3 receptors increases the number of lamellipodia. [4]
  • PGE1

Anatomical structures with this receptor

  • large_intestine

  • small_intestine

  • lung

  • kidney

  • thymus

  • uterus

  • brain

  • circulatory_system__hematopoietic_system

  • cell_of_endometrium_of_uterus

  • osteoblast

    Influences

    • positive interleukin 6
      • Il-6 is produced by osteoblasts, and its production is stimulated by PTH and PGE2. [5]
    • positive amphiregulin
      • In addition to PTH, PGE2 also strongly stimulates AR expression through the CREB phosphorylation pathway. [6]

  • osteoclast

  • monocyte

    Influences

    • negative IL-12
      • PGE2 inhibits IL-12 production via EP4 receptors by monocytes challenged with A. actinomycetemcomitans-LPS and IFN-gamma. [7]
    • negative TNF-alpha
      • EP4 receptors are involved in the regulation of TNF-alpha production in monocytes. [7]
      • PGE1, PGE2 and cicaprost suppressed the elaboration of TNF-alpha in LPS-stimulated cells in a concentration-dependent manner. TNF-alpha generation was inhibited by 85 to 90% at the highest concentration (10 mM) of agonist tested. [8]
Reference