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Details for receptor: PGI receptor

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EndoNet ID: ENR00733

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As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • IP
  • prostanoid IP receptor
  • PGI receptor
  • prostaglandin I2 receptor
  • prostacyclin receptor

General information

  • The human prostacyclin receptor (hIP) is isoprenylated in whole cells. [1]
  • The human prostacyclin receptor (hIP) consistes of seven transmembrane-spanning G-proteins. [2]
  • The phosphorylation of the prostacyclin receptor by protein kinase C causes the rapid desensitization of the human prostacyclin. [3]

Links to other resources

UniProt P43119
Ensembl ENST00000291294

Subunit information

Sequence 
MADSCRNLT YVRGSVGPA TSTLMFVAG 
VVGNGLALG ILSARRPAR PSAFAVLVT 
GLAATDLLG TSFLSPAVF VAYARNSSL 
LGLARGGPA LCDAFAFAM TFFGLASML 
ILFAMAVER CLALSHPYL YAQLDGPRC 
ARLALPAIY AFCVLFCAL PLLGLGQHQ 
QYCPGSWCF LRMRWAQPG GAAFSLAYA 
GLVALLVAA IFLCNGSVT LSLCRMYRQ 
QKRHQGSLG PRPRTGEDE VDHLILLAL 
MTVVMAVCS LPLTIRCFT QAVAPDSSS 
EMGDLLAFR FYAFNPILD PWVFILFRK 
AVFQRLKLW VCCLCLGPA HGDSQTPLS 
QLASGRRDP RAPSAPVGK EGSCVPLSA 
WGEGQVEPL PPTQQSSGS AVGTSSKAE 
ASVACSLC

Binding hormones

  • PGI2
  • PGE1
    • PGE1 and its analogues (butaprost, misoprostol) are moderately potent agonists at the IP-receptor. [4]

Anatomical structures with this receptor

  • lung

  • placenta

  • pancreas

  • monocyte

  • platelet

Reference