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Details for receptor: SPR

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EndoNet ID: ENR00734

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Synonyms

  • NK-1R
  • SPR
  • NK-1 receptor
  • substance-P receptor
  • tachykinin receptor 1
  • neurokinin 1 receptor
  • SP receptor
  • TACR1
  • NK1R

General information

  • Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis. [1]
  • The substance P (SP)-preferring receptor neurokinin-1 receptor (NK-1R) has two forms: a full-length receptor consisting of 407 aa and a truncated receptor consisting of 311 aa. These two receptors differ in the length of the C terminus. [2]
  • Rank order of affinity to tachykinins is: substance P > substance K > neuromedin K. [3]
  • Substance P induces expression of the corticotropin-releasing factor receptor 1 by activation of the neurokinin-1 receptor. [4]
  • SP and NK1R signaling contributes to the innate resistance against HSV-2 infection. [5]
  • Interleukin-1beta upregulates functional expression of neurokinin-1 receptor (NK-1R) via NF-kappaB in astrocytes. [6]
  • expression of the SPR gene is selectively and negatively regulated by glucocorticoids [7]
  • expressed in CNS and periphery. Central NK-1R involved in nociceptive transmission, anxiety and depression
  • interaction occurs in several cell systems and is involved in exocrine gland secretion (e.g., sialogogue), endocrine secretion, pain transmission, vasodilatation, connective-tissue cell proliferation, and neuroimmune modulation. [8]

Links to other resources

UniProt P25103
Ensembl ENST00000409848

Subunit information

Sequence 
MDNVLPVDS DLSPNISTN TSEPNQFVQ 
PAWQIVLWA AAYTVIVVT SVVGNVVVM 
WIILAHKRM RTVTNYFLV NLAFAEASM 
AAFNTVVNF TYAVHNEWY YGLFYCKFH 
NFFPIAAVF ASIYSMTAV AFDRYMAII 
HPLQPRLSA TATKVVICV IWVLALLLA 
FPQGYYSTT ETMPSRVVC MIEWPEHPN 
KIYEKVYHI CVTVLIYFL PLLVIGYAY 
TVVGITLWA SEIPGDSSD RYHEQVSAK 
RKVVKMMIV VVCTFAICW LPFHIFFLL 
PYINPDLYL KKFIQQVYL AIMWLAMSS 
TMYNPIIYC CLNDRFRLG FKHAFRCCP 
FISAGDYEG LEMKSTRYL QTQGSVYKV 
SRLETTIST VVGAHEEEP EDGPKATPS 
SLDLTSNCS SRSDSKTMT ESFSFSSNV 
LS

Binding hormones

  • hemokinin
  • neuromedin-K
  • SP
  • neurokinin A

Anatomical structures with this receptor

  • corpus_striatum

    Induced phenotypes

    • sensory perception of pain
      • SP modulates pain centrally and peripherally. Receptor expression has high density in the striatum, amygdala and dorsolaterla prefrontal cortex [9]
Reference