Status
Please wait ...

Details for receptor: sst5

  • Top
  • General information
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00739

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • sst5
  • sst(5)
  • SSTR5
  • somatostatin receptor 5

General information

  • SSTR5 colocalized with glucagon in 35 of alpha-cells. [1]
  • SSTR5 was also an abundant isotype, being colocalized with insulin in 87% of beta-cells. [1]
  • SSTR5 was preferentially expressed in 75% of SST-positive cells and was the principal delta-cell SSTR subtype. [1]
  • Belongs to the seven transmembrane domain receptor family. [2]

Links to other resources

UniProt P35346
Ensembl ENST00000397547

Binding hormones

  • cortistatin
    • CST-17 and its rodent homologue CST-14 both bind nonselectively and with nanomolar affinities to all five somatostatin receptor subtypes in vitro. [3]
  • somatostatin
    • Works better with SST-28 than with SST-14.
  • somatostatin-14
  • somatostatin-28

Anatomical structures with this receptor

  • basophil_thyrotroph_cell_of_anterior_pituitary

    Influences

    • negative TSH

  • brain

  • pituitary_gland_of_diencephalon

    Influences

    • negative PRL
      • PRL secretion was inhibited in sst5-expressing tumors [4]
    • negative ACTH
      • Selective sst5 activation regulates sst2 signaling resulting in an inhibition of ACTH secretion from pituitary tumor cells. [5]

  • acidophil_somatotroph_cell_of_anterior_pituitary

    Influences

    • negative GH
      • SSTR2 and SSTR5 mediate suppression of GH and TSH secretion. [6]
      • SRIF and CST similarly inhibited (p < 0.05) spontaneous GH secretion of about 90%. [7]
      • Somatostatin induced inhibition of GH secretion is mediated through (SSTR) 2 and 5. [8]

  • stomach

  • alpha_cell_of_islet_of_Langerhans

    Influences

    • negative glucagon

  • D_cell

    Influences

    • negative somatostatin

  • beta_cell_of_islet_of_Langerhans

    Influences

    • negative insulin
Reference