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Details for receptor: VPAC2

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EndoNet ID: ENR00742

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Synonyms

  • vasoactive intestinal peptide receptor 2
  • VPAC2
  • PACAP-R-3
  • helodermin-preferring VIP receptor
  • PACAP type III receptor
  • VIP-2R

General information

  • Receptor for VIP, PACAP-38 and -27.

Links to other resources

UniProt P41587
Ensembl ENST00000437234

Subunit information

Subunit (1 times)

Sequence 
MRTLLPPAL LTCWLLAPV NSIHPECRF 
HLEIQEEET KCAELLRSQ TEKHKACSG 
VWDNITCWR PANVGETVT VPCPKVFSN 
FYSKAGNIS KNCTSDGWS ETFPDFVDA 
CGYSDPEDE SKITFYILV KAIYTLGYS 
VSLMSLATG SIILCLFRK LHCTRNYIH 
LNLFLSFIL RAISVLVKD DVLYSSSGT 
LHCPDQPSS WVGCKLSLV FLQYCIMAN 
FFWLLVEGL YLHTLLVAM LPPRRCFLA 
YLLIGWGLP TVCIGAWTA ARLYLEDTG 
CWDTNDHSV PWWVIRIPI LISIIVNFV 
LFISIIRIL LQKLTSPDV GGNDQSQYK 
RLAKSTLLL IPLFGVHYM VFAVFPISI 
SSKYQILFE LCLGSFQGL VVAVLYCFL 
NSEVQCELK RKWRSRCPT PSASRDYRV 
CGSSFSRNG SEGALQFHR GSRAQSFLQ 
TETSVI
UniProt P41587-1

Binding hormones

  • VIP
  • pituitary adenylate cyclase-activating polypeptide

Anatomical structures with this receptor

  • helper_T_cell_Th1

    Induced phenotypes

    • cell maturation
      • In CD4+CD8+thymocytes, PACAP prevents glucocorticoid-induced apoptosis by inhibiting Fas ligand expression, suggesting a possible implication in intrathymic T-cell maturation. [1]
    • Stimulation through the T cell receptors-associated CD3 complex induces the expression of the VPAC2-R mRNA in T-lymphocytes. [2]

  • cell_of_adrenal_gland_zona_glomerulosa

    Influences

    • positive aldosterone
      • VIP and PACAP, acting via VPAC1 coupled to adenylate cyclase- and phospholipase C-dependent cascades, stimulate aldosterone secretion from zona glomerulosa cells. [3]

  • adrenal_medulla

    Influences

    • positive ACTH
      • There is proof that VIP and PACAP can also enhance aldosterone secretion indirectly, by eliciting the release from medullary chromaffin cells of catecholamines and adrenocorticotropic hormone, which in turn may act on the cortical cells in a paracrine manner. [3]
    • positive dopamine
      • VIP and PACAP stimulate the synthesis and release of adrenomedullary catecholamines, and all three subtypes of PACAP/VIP receptors mediate this effect, VPAC2 being coupled to PLC. [3]
    • positive norepinephrine
      • VIP and PACAP stimulate the synthesis and release of adrenomedullary catecholamines, and all three subtypes of PACAP/VIP receptors mediate this effect, VPAC2 being coupled to PLC. [3]
    • positive epinephrine
      • VIP and PACAP stimulate the synthesis and release of adrenomedullary catecholamines, and all three subtypes of PACAP/VIP receptors mediate this effect,VPAC2 being coupled to PLC. [3]

  • chromaffin_cell

    Induced phenotypes

    • positive regulation of catecholamine secretion
      • PAPAC38 concentration-dependently increases catecholamine secretion from AM tissue. [4]

  • acinar_cell_of_pancreas

    Induced phenotypes

    • positive regulation of secretion
      • Both VIP receptor subtypes exist on pancreatic acini of rat and guinea pig, their activation stimulates enzyme secretion by a cAMP-mediated mechanism, and the effects of VIP are mediated 90% by activation of VPAC1 and 10% by VPAC2. [5]
    • Both VPAC1 and VPAC2 subtypes exist on pancreatic acini of rat and guinea pig. [5]
Reference