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Details for receptor: V1b

EndoNet ID: ENR00744

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  • V1b
  • antidiuretic hormone receptor 1b
  • AVPR V1b
  • V3
  • vasopressin receptor 1b

General information

  • V3 enhances ACTH release in pituitary corticotrophs. [1]
  • RT-PCR analysis shows that the human V3 receptor is expressed in normal pituitary and also in kidney. [2]

Links to other resources

UniProt P47901
Ensembl ENST00000367126

Binding hormones

  • antidiuretic hormone
  • Oxytocin-Neurophysin 1

Anatomical structures with this receptor

  • basophil_corticotroph_cell_of_anterior_pituitary


    • positive ACTH
      • Vasopressin is an important regulator of pituitary adrenocorticotropin (ACTH) secretion, mainly by potentiating the stimulatory effect of corticotropin releasing hormone. [3]
      • Effect of vasopressin in the pituitary corticotrope cells are mediated by the vasopressin type 1b receptor subtype, which is coupled to phospholipase C, leading to increases in cytosolic calcium and activation of protein kinase C. [3]
  • kidney

  • thymus

    Induced phenotypes

    • regulation of T cell differentiation
      • Thymic oxytocin and vasopressin might play an active role in T cell differentiation and activation. [4]