Status
Please wait ...

Details for receptor: V1b

  • Top
  • General information
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00744

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • V1b
  • antidiuretic hormone receptor 1b
  • AVPR V1b
  • V3
  • vasopressin receptor 1b

General information

  • V3 enhances ACTH release in pituitary corticotrophs. [1]
  • RT-PCR analysis shows that the human V3 receptor is expressed in normal pituitary and also in kidney. [2]

Links to other resources

UniProt P47901
Ensembl ENST00000367126

Binding hormones

  • antidiuretic hormone
  • Oxytocin-Neurophysin 1

Anatomical structures with this receptor

  • basophil_corticotroph_cell_of_anterior_pituitary

    Influences

    • positive ACTH
      • Vasopressin is an important regulator of pituitary adrenocorticotropin (ACTH) secretion, mainly by potentiating the stimulatory effect of corticotropin releasing hormone. [3]
      • Effect of vasopressin in the pituitary corticotrope cells are mediated by the vasopressin type 1b receptor subtype, which is coupled to phospholipase C, leading to increases in cytosolic calcium and activation of protein kinase C. [3]

  • kidney

  • thymus

    Induced phenotypes

    • regulation of T cell differentiation
      • Thymic oxytocin and vasopressin might play an active role in T cell differentiation and activation. [4]
Reference