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Details for receptor: OTR

EndoNet ID: ENR00746

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Synonyms

  • OXTR
  • oxytocin receptor
  • OTR

General information

  • The encoded receptor is a 389 amino acid polypeptide with 7 transmembrane domains and belongs to the class I G protein-coupled receptor family. [1]

Links to other resources

UniProt P30559
Ensembl ENST00000449615

Subunit information

oxytocin receptor

Sequence
MEGALAANW SAEAANASA APPGAEGNR 
TAGPPRRNE ALARVEVAV LCLILLLAL 
SGNACVLLA LRTTRQKHS RLFFFMKHL 
SIADLVVAV FQVLPQLLW DITFRFYGP 
DLLCRLVKY LQVVGMFAS TYLLLLMSL 
DRCLAICQP LRSLRRRTD RLAVLATWL 
GCLVASAPQ VHIFSLREV ADGVFDCWA 
VFIQPWGPK AYITWITLA VYIVPVIVL 
AACYGLISF KIWQNLRLK TAAAAAAEA 
PEGAAAGDG GRVALARVS SVKLISKAK 
IRTVKMTFI IVLAFIVCW TPFFFVQMW 
SVWDANAPK EASAFIIVM LLASLNSCC 
NPWIYMLFT GHLFHELVQ RFLCCSASY 
LKGRRLGET SASKKSNSS SFVLSHRSS 
SQRSCSQPS TA

Binding hormones

  • Oxytocin-Neurophysin 1

Anatomical structures with this receptor

  • thymus

    Induced phenotypes

    • thymocyte proliferation
      • The neurohypophysial peptides have been shown to trigger thymocyte proliferation and could induce immune tolerance of this conserved neuroendocrine family [1]
  • mammary_gland

    Induced phenotypes

    • milk ejection
Reference