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Details for receptor: PACAP-R-1

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EndoNet ID: ENR00747

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Synonyms

  • PACAP type I receptor
  • pituitary adenylate cyclase activating peptide r 1
  • PAC 1
  • PACAP-R-1

General information

  • Receptor for PACAP-27 and PACAP-38. [1]
  • Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta. [1]

Links to other resources

UniProt P41586
Ensembl ENST00000436116

Subunit information

Subunit (1 times)

Sequence 
MAGVVHVSL AALLLLPMA PAMHSDCIF 
KKEQAMCLE KIQRANELM GFNDSSPGC 
PGMWDNITC WKPAHVGEM VLVSCPELF 
RIFNPDQVW ETETIGESD FGDSNSLDL 
SDMGVVSRN CTEDGWSEP FPHYFDACG 
FDEYESETG DQDYYYLSV KALYTVGYS 
TSLVTLTTA MVILCRFRK LHCTRNFIH 
MNLFVSFML RAISVFIKD WILYAEQDS 
NHCFISTVE CKAVMVFFH YCVVSNYFW 
LFIEGLYLF TLLVETFFP ERRYFYWYT 
IIGWGTPTV CVTVWATLR LYFDDTGCW 
DMNDSTALW WVIKGPVVG SIMVNFVLF 
IGIIVILVQ KLQSPDMGG NESSIYLRL 
ARSTLLLIP LFGIHYTVF AFSPENVSK 
RERLVFELG LGSFQGFVV AVLYCFLNG 
EVQAEIKRK WRSWKVNRY FAVDFKHRH 
PSLASSGVN GGTQLSILS KSSSQIRMS 
GLPADNLAT
UniProt P41586-1

Binding hormones

    Anatomical structures with this receptor

    • brain

      Induced phenotypes

      • negative regulation of neuron apoptosis
        • PACAP-38 has an antiapoptotic effect on neurons, it increases survival of cerebellar neurons in a dose-dependent manner by decreasing the extent of apoptosis estimated by DNA fragmentation. PACAP-38 induced activation of the extracellular signal-regulated kinase (ERK)-type of mitogen-activated protein (MAP) kinase through a cAMP-dependent pathway. [2]

    • lung

      Induced phenotypes

      • regulation of cell proliferation
        • In the small cell lung tumor cell line NCI-H345, PACAP stimulates cell proliferation through the activation of type II binding sites. [3]

    • thymus

      Induced phenotypes

      • negative regulation of chemotaxis
        • PACAP decreases chemotaxis of thymocytes and splenic lymphocytes through activation of the PKA pathway . [4]

    • spleen

      Induced phenotypes

      • negative regulation of IL-10 production
        • In murine spleen cells and thymocytes, PACAP inhibits IL-10 production via both cAMP-dependent and cAMP-independent transduction pathways. [5]

    • pancreas

      Influences

      • insulin
        • The signaling phenotype of PACAPR TM4 (Pituitary adenylate cyclase-activating polypeptide transmembrane domain IV) is characteristic of the PACAP receptor involved in regulation of insulin secretion from pancreatic β islets, a tissue expressing transcripts for PACAPR TM4 but not for PACAPR or its longer splice variant forms. These findings are consistent with a role of PACAPR TM4 in the physiological control of insulin release by PACAP in β-islet cells. [6]

    • placenta

      Induced phenotypes

      • positive regulation of vasodilation
        • PACAP has been detected at low concentrations throughout the uteroplacental unit, where it causes a concentration-dependent relaxation on stem villous and umbilical cord arteries. [7]

    • adrenal_medulla

      Influences

      • positive dopamine
        • VIP and PACAP stimulate the synthesis and release of adrenomedullary catecholamines, and all three subtypes of PACAP/VIP receptors mediate this effect, PACAP-R-1 being coupled to AC. [8]
      • positive norepinephrine
        • VIP and PACAP stimulate the synthesis and release of adrenomedullary catecholamines, and all three subtypes of PACAP/VIP receptors mediate this effect, PACAP-R-1 being coupled to AC. [8]
      • positive epinephrine
        • VIP and PACAP stimulate the synthesis and release of adrenomedullary catecholamines, and all three subtypes of PACAP/VIP receptors mediate this effect, PAC(1)-Rs being coupled to AC. [8]
      • PACAP-R-1 expression exclusively occurs in the adrenal medulla. [9]

    • chromaffin_cell

      Induced phenotypes

      • positive regulation of catecholamine secretion
        • PAPAC38 concentration-dependently increases catecholamine secretion from AM tissue. [9]
      • PACAP-R-1 expression exclusively occurs in the adrenal medulla. [9]
    Reference