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Details for receptor: H2

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  • Hormones
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EndoNet ID: ENR00749

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Synonyms

  • gastric receptor I
  • H2R
  • H2
  • histamine receptor 2

General information

  • Studies with antagonists have demonstrated the importance of the H2 receptor in the regulation of gastric acid secretion, contraction of the heart, gastrointestinal motility, cell differentiation and cell proliferation. [1]
  • Activated intracellular signals: adenylate cyclase, cAMP, c-Fos, c-Jun, PKC, p70S6K. [2]
  • Expression in nerve cells, airway and vascular smooth muscles, hepatocytes, chondrocytes, endothelial cells, epithelial cells, neutrophils, eosinophils, monocytes, dendritic cells, T and B cells. [2]
  • H2 receptor mRNA levels decrease with the progression of gastric atrophy induced by Helicobacter pylori infection, and are restored after H. pylori eradication. [3]

Links to other resources

UniProt P25021
Ensembl ENST00000393749

Binding hormones

  • histamine

Anatomical structures with this receptor

  • mucosa_of_gastric_wall

  • nerve

  • hepatocyte

  • chondrocyte

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

  • epithelial_cell

  • neutrophil_granulocyte

  • eosinophil_granulocyte

  • monocyte

  • dendritic_cell_in_lymphoid_tissues

  • B-lymphocyte

  • T-lymphocyte

  • oxyntic_cell_of_gastric_gland

    Induced phenotypes

    • positive regulation of gastric acid secretion
      • Because histamine represents a potent stimulant for gastric acid secretion, H2-receptor antagonists are widely used for the treatment of acid-related peptic disease. [4]
Reference