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Details for receptor: 5-ht-6R

EndoNet ID: ENR00751

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  • 5-hydroxytryptamine receptor 6
  • serotonin receptor 6
  • 5-ht-6R

General information

Links to other resources

UniProt P50406
Ensembl ENST00000289753

Binding hormones

  • serotonin

Anatomical structures with this receptor

  • central_nerve_system_element

  • corpus_striatum

  • cerebellar_cortex

  • hippocampus


    • positive GABA
      • The activation of 5-HT6 receptors cause an increase in spontaneous release of GABA. [1]
  • frontal_lobe


    • negative glutamate
      • The stimulation of the 5-HT6 receptor by the antagonist SB-271046 produce a significant increase in extracellular glutamate concentration. [2]
    • negative L-aspartate
      • The stimulation of 5-HT6 receptor by the antagonist SB-271046 mediate a significant increase in extracellular aspartat concentration. [2]
    • negative acetylcholine
      • The stimulation of 5-HT6 receptors mediate an inhibitory serotoninergic effect to the ACh release in the frontal cortex. [3]
      • Constitutively activated 5-HT6 receptors inhibite cholinergic neurotransmission. [4]