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Details for receptor: LTB4-R1

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EndoNet ID: ENR00753

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Synonyms

  • BLT
  • leukotriene B4 receptor 1
  • LTB4 receptor
  • LTB4-R
  • P2Y purinoceptor 7
  • P2Y7
  • BLT1
  • LTB4-R 1
  • chemoattractant receptor-like 1
  • G-protein coupled receptor 16
  • LTB4R
  • BLTR
  • CMKRL1
  • GPR16
  • LTB4-R1

General information

  • G protein-coupled seven transmembrane domain receptor. [1]
  • The two receptors for leukotriene B(4) differ in their affinity and specificity for LTB(4): BLT1 is a high-affinity receptor specific for LTB(4), whereas BLT2 is a low-affinity receptor that also binds other eicosanoids. [1]

Links to other resources

UniProt Q15722
Ensembl ENST00000396789

Subunit information

Leukotriene B4 receptor 1

Sequence 
MNTTSSAAP PSLGVEFIS LLAIILLSV 
ALAVGLPGN SFVVWSILK RMQKRSVTA 
LMVLNLALA DLAVLLTAP FFLHFLAQG 
TWSFGLAGC RLCHYVCGV SMYASVLLI 
TAMSLDRSL AVARPFVSQ KLRTKAMAR 
RVLAGIWVL SFLLATPVL AYRTVVPWK 
TNMSLCFPR YPSEGHRAF HLIFEAVTG 
FLLPFLAVV ASYSDIGRR LQARRFRRS 
RRTGRLVVL IILTFAAFW LPYHVVNLA 
EAGRALAGQ AAGLGLVGK RLSLARNVL 
IALAFLSSS VNPVLYACA GGGLLRSAG 
VGFVAKLLE GTGSEASST RRGGSLGQT 
ARSGPAALE PGPSESLTA SSPLKLNEL 
N
UniProt Q15722

Binding hormones

  • LTB4-d4
  • LTB4
  • 12-epi-LTB4
  • 20-carboxy-LTB4
  • 14,15-dehydro-LTB4
    • G-protein coupled receptor: activation of phosphoinositide (PI)-specific phospholipase C : increase in intracellular Ca2+ concentration [2]
  • 12-keto-10,11,14,15-tetrahydro-LTB4
  • LTB4 ethanol amide
  • 12-oxo-LTB4
  • 6-trans-LTB4
  • LTB4 dimethyl amide
  • 20-hydroxy LTB4

Anatomical structures with this receptor

  • heart

  • skeleton_muscle

  • brain

  • lymphoid_tissue

  • leukocyte

Reference