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Details for receptor: Sphingosine 1-phosphate receptor 3

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EndoNet ID: ENR00757

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Synonyms

  • edg3
  • Sphingosine 1-phosphate receptor 3
  • S1PR3
  • Sphingosine 1-phosphate receptor Edg-3
  • Endothelial differentiation G-protein coupled receptor 3

General information

  • Belongs to the G-protein coupled receptor 1 family.

Links to other resources

UniProt Q99500
Ensembl ENST00000375846

Subunit information

Subunit (1 times)

Sequence 
MATALPPRL QPVRGNETL REHYQYVGK 
LAGRLKEAS EGSTLTTVL FLVICSFIV 
LENLMVLIA IWKNNKFHN RMYFFIGNL 
ALCDLLAGI AYKVNILMS GKKTFSLSP 
TVWFLREGS MFVALGAST CSLLAIAIE 
RHLTMIKMR PYDANKRHR VFLLIGMCW 
LIAFTLGAL PILGWNCLH NLPDCSTIL 
PLYSKKYIA FCISIFTAI LVTIVILYA 
RIYFLVKSS SRKVANHNN SERSMALLR 
TVVIVVSVF IACWSPLFI LFLIDVACR 
VQACPILFK AQWFIVLAV LNSAMNPVI 
YTLASKEMR RAFFRLVCN CLVRGRGAR 
ASPIQPALD PSRSKSSSS NNSSHSPKV 
KEDLPHTAP SSCIMDKNA ALQNGIFCN
UniProt Q99500-1

Binding hormones

  • sphingosine 1-phosphate
    • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P).
  • Sphingosylphosphorylcholine
    • All of the subsequently identified S1P receptors of the EDG family exhibited a low affinity for SPC and might thus rather mediate some of SPC's extracellular actions in the low micromolar concentration range. [1]

Anatomical structures with this receptor

  • heart

  • placenta

  • kidney

  • liver

    Induced phenotypes

    • hepatic stellate cell migration
      • S1P3 regulates migration and fibrogenic activation of HSCs. [2]

  • immune_system

  • dendritic_cell_in_lymphoid_tissues

    Induced phenotypes

    • dendritic cell chemotaxis
      • DCs mainly express S1PR1 when immature but on maturation upregulate S1PR3, which then seems to mediate a chemotatic response to S1P. [3]
    • positive regulation of endocytosis
      • S1P has been shown to increase endocytosis by mature DCs through S1PR3 engagement. [4]
      • This S1P-mediated enhancement of endocytosis in mature DCs could be involved in the removal of bacteria during infection. [4]
    • positive regulation of interleukin-1 beta production
      • S1PR3 is essential for inducing the production of IL-1beta and tissue factor and for their dissemination into the lung circulation, thereby amplifying inflammation and coagulation. [5]

  • eosinophil_granulocyte

  • B-lymphocyte

  • T-lymphocyte

    Induced phenotypes

    • negative regulation of T cell apoptosis
      • Protection of T lymphocytes from apoptosis by S1P was associated with suppression of Bax expression via an EDG5- and EDG3-dependent mechanism. [6]

  • spleen

  • lung

    Induced phenotypes

    • adherens junction assembly
      • Intravenous S1P infusion results in rapid and significant reduction of lung weight gain and significantl reduces microvascular permeabilit and inflammation after acute lung injury, consistent with systemic barrier enhancement. [7]
      • S1P induces cortical reorganization of the endothelial cytoskeleton and the distribution, assembly and stabilization of adherens junctions and focal adhesion complexes on the cell membrane via S1P3 receptor signaling and activation of Rac. [8]

  • thymus

  • testis

    Induced phenotypes

    • reproduction
      • S1P3 null mice were fertile but the litter sizes were slightly smaller. This suggests a role of S1P3 in reproduction, in agreement with the expression of these receptors in the gonads. [9]

  • brain

  • skeleton_muscle

  • pancreas

  • smooth_muscle_cell

    Induced phenotypes

    • vasoconstriction
      • S1P induces the vasoconstriction of isolated canine cerebral arteries via S1P receptor 3. [10]
    • regulation of inflammatory response
      • In vascular smooth muscle cells, S1P stimulates DNA synthesis in association with ERK activation, and may play a central role in excessive fibroproliferative and inflammatory response to vascular injury that are hallmarks of atherosclerois progression. [7]

  • vascularendothelial_cell

    Induced phenotypes

    • positive regulation of endothelial cell proliferation
      • S1P induces proliferation of VECs. [11]
      • S1P receptor-mediated signaling plays a major regulatory role in angiogenesis. [12]
    • positive regulation of blood vessel endothelial cell migration
      • S1P induces migration of VECs. [13]
      • S1P receptor-mediated signaling plays a major regulatory role in angiogenesis. [12]
      • VEC migration is inhibited by antisense oligonucleotides against s1p3. [14]
    • adherens junction assembly
      • S1P-induced VEC adherens junction assembly and cell barrier integrity are blocked by antisense oligonucleotides against s1p3. [15]
      • S1P stimulates the formation and maintenance of VECs assembly/integrity by activating S1P3. [16]

  • keratinocyte

Reference