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Details for receptor: MC1R

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EndoNet ID: ENR00760

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Synonyms

  • MC1R
  • melanocyte-stimulating hormone receptor
  • melanocortin receptor 1
  • melanotropin receptor
  • MSH-R
  • MC1-R
  • MC1

General information

  • Regulates skin and hair pigmentation. [1]
  • MC1R is expressed by cutaneous melanocytes, where it has a key role in determining skin and hair pigmentation. [2]
  • Specific products were identified for MC1R in pituitary and testis. [3]
  • Membrane protein in melanocytes and corticoadrenal tissue. [1]
  • Coupled with G-protein that activates adenylyl cyclase. [1]
  • Receptor for MSH (alpha, beta and gamma) and ACTH. [1]

Links to other resources

UniProt Q01726
Ensembl ENST00000315491

Subunit information

Sequence 
MAVQGSQRR LLGSLNSTP TAIPQLGLA 
ANQTGARCL EVSISDGLF LSLGLVSLV 
ENALVVATI AKNRNLHSP MYCFICCLA 
LSDLLVSGS NVLETAVIL LLEAGALVA 
RAAVLQQLD NVIDVITCS SMLSSLCFL 
GAIAVDRYI SIFYALRYH SIVTLPRAR 
RAVAAIWVA SVVFSTLFI AYYDHVAVL 
LCLVVFFLA MLVLMAVLY VHMLARACQ 
HAQGIARLH KRQRPVHQG FGLKGAVTL 
TILLGIFFL CWGPFFLHL TLIVLCPEH 
PTCGCIFKN FNLFLALII CNAIIDPLI 
YAFHSQELR RTLKEVLTC SW

Binding hormones

  • melanotropin beta
    • The potency of MC1R-Ligands is alpha-MSH = ACTH > beta-MSH > gamma-MSH. [2]
  • melanotropin gamma
    • The potency of MC1R-Ligands is alpha-MSH = ACTH > beta-MSH > gamma-MSH. [2]
  • alpha-MSH
    • Activation of MC1R by alpha -MSH stimulates eumelanin synthesis in the melanocytes. [2]
    • MC1R is the "classical" melanocyte alpha -MSH receptor. [2]
    • The potency of MC1R-Ligands is alpha-MSH = ACTH > beta-MSH > gamma-MSH. [2]
  • ACTH
    • The potency of MC1R-Ligands is alpha-MSH = ACTH > beta-MSH > gamma-MSH. [2]

Anatomical structures with this receptor

  • melanocyte

    Influences

    • MSH

    Induced phenotypes

    • melanin synthesis
      • Alpha-MSH acts as an agonist by binding to melanocortin receptor 1 (MC1-R) and elevting intracellular cAMP to induce eumelanin synthesis in the follicular melanocytes. [4]
    • antiapoptotic effect
      • The antiapoptotic effect of alpha-MSH was linked to reduction in cyclopyrimidine dimers, the major UV-induced DNA photoproduct. The antiapoptotic effects of alpha-MSH and the reduction in UVB-induced cyclopyrimidine dimers were not observed in melanocytes expressing loss-of function mutation of MC-1R. [5]

  • Leydig_cell_of_testis

  • placenta

  • skin

    Influences

    • MSH

  • testis

  • hair_follicle

  • keratinocyte

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

  • fibroblast

    Induced phenotypes

    • suppression of interstitial fibrosis
      • Alpha-MSH suppressed interstitial fibrosis induced by TGF-beta1 and reduced the number of vimentin and alpha-smooth muscle actin positive cells. [6]
Reference