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Details for receptor: NPY1-R

EndoNet ID: ENR00765

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Synonyms

  • neuropeptide Y receptor 1
  • NPY1-R
  • NPY1R

General information

  • CGRP-R, NPY-R, VIP-1R and beta2-R, but not SP-R, VIP-2R, PACAP-R, beta1-R and beta3-R, were expressed in osteoblasts as well as osteosarcoma cells. [1]
  • Rank order of affinity for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. [2]

Links to other resources

UniProt P25929
Ensembl ENST00000296533

Subunit information

Sequence
MNSTLFSQV ENHSVHSNF SEKNAQLLA 
FENDDCHLP LAMIFTLAL AYGAVIILG 
VSGNLALII IILKQKEMR NVTNILIVN 
LSFSDLLVA IMCLPFTFV YTLMDHWVF 
GEAMCKLNP FVQCVSITV SIFSLVLIA 
VERHQLIIN PRGWRPNNR HAYVGIAVI 
WVLAVASSL PFLIYQVMT DEPFQNVTL 
DAYKDKYVC FDQFPSDSH RLSYTTLLL 
VLQYFGPLC FIFICYFKI YIRLKRRNN 
MMDKMRDNK YRSSETKRI NIMLLSIVV 
AFAVCWLPL TIFNTVFDW NHQIIATCN 
HNLLFLLCH LTAMISTCV NPIFYGFLN 
KNFQRDLQF FFNFCDFRS RDDDYETIA 
MSTMHTDVS KTSLKQASP VAFKKINNN 
DDNEKI

Binding hormones

  • pancreatic polypeptide
  • NPY
  • PYY (1-36)

Anatomical structures with this receptor

  • osteoblast

  • arcuate_nucleus_of_hypothalamus

    Induced phenotypes

    • positive regulation of appetite
      • The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake. [3]
Reference