Status
Please wait ...

Details for receptor: NPY4-R

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00766

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • PPYR1
  • neuropeptide Y receptor 4
  • NPY4-R
  • NPY4R

General information

  • Highest levels in brain, coronary artery and ileum, low levels in pancreas and kidney, detected in colon and small intestine. [1]
  • Rank order of affinity for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid. [1]

Links to other resources

UniProt P50391
Ensembl ENST00000395716

Subunit information

Sequence 
MNTSHLLAL LLPKSPQGE NRSKPLGTP 
YNFSEHCQD SVDVMVFIV TSYSIETVV 
GVLGNLCLM CVTVRQKEK ANVTNLLIA 
NLAFSDFLM CLLCQPLTA VYTIMDYWI 
FGETLCKMS AFIQCMSVT VSILSLVLV 
ALERHQLII NPTGWKPSI SQAYLGIVL 
IWVIACVLS LPFLANSIL ENVFHKNHS 
KALEFLADK VVCTESWPL AHHRTIYTT 
FLLLFQYCL PLGFILVCY ARIYRRLQR 
QGRVFHKGT YSLRAGHMK QVNVVLVVM 
VVAFAVLWL PLHVFNSLE DWHHEAIPI 
CHGNLIFLV CHLLAMAST CVNPFIYGF 
LNTNFKKEI KALVLTCQQ SAPLEESEH 
LPLSTVHTE VSKGSLRLS GRSNPI

Binding hormones

  • PYY(3-36)
  • NPY
  • pancreatic polypeptide
  • PYY (1-36)

Anatomical structures with this receptor

  • pancreas

  • kidney

  • colon

  • small_intestine

  • ileum

  • right_coronary_artery

  • arcuate_nucleus_of_hypothalamus

    Induced phenotypes

    • positive regulation of appetite
      • The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake. [2]

  • left coronary artery

Reference