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Details for receptor: NPY5-R

EndoNet ID: ENR00767

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Synonyms

  • neuropeptide Y receptor 5
  • NPY5-R
  • NPY5R

General information

  • Neuropeptide Y receptor Y5, a G protein-coupled receptor that signals through cAMP inhibition and calcium flux, may modulate appetite and seizure activit.
  • The arcuate nucleus being particularly enriched compared to other hypothalamic nuclei. [1]

Links to other resources

UniProt Q15761
Ensembl ENST00000338566

Subunit information

Sequence
MSFYSKQDY NMDLELDEY YNKTLATEN 
NTAATRNSD FPVWDDYKS SVDDLQYFL 
IGLYTFVSL LGFMGNLLI LMALMKKRN 
QKTTVNFLI GNLAFSDIL VVLFCSPFT 
LTSVLLDQW MFGKVMCHI MPFLQCVSV 
LVSTLILIS IAIVRYHMI KHPISNNLT 
ANHGYFLIA TVWTLGFAI CSPLPVFHS 
LVELQETFG SALLSSRYL CVESWPSDS 
YRIAFTISL LLVQYILPL VCLTVSHTS 
VCRSISCGL SNKENRLEE NEMINLTLH 
PSKKSGPQV KLSGSHKWS YSFIKKHRR 
RYSKKTACV LPAPERPSQ ENHSRILPE 
NFGSVRSQL SSSSKFIPG VPTCFEIKP 
EENSDVHEL RVKRSVTRI KKRSRSVFY 
RLTILILVF AVSWMPLHL FHVVTDFND 
NLISNRHFK LVYCICHLL GMMSCCLNP 
ILYGFLNNG IKADLVSLI HCLHM

Binding hormones

  • NPY
  • PYY(3-36)
  • PYY (1-36)

Anatomical structures with this receptor

  • amygdaloid_body

  • smooth_muscle

  • blood_vessel

  • arcuate_nucleus_of_hypothalamus

    Influences

    • GnRH-I

    Induced phenotypes

    • positive regulation of appetite
      • The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake. [2]
  • hypothalamus

Reference