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Details for receptor: EP1

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EndoNet ID: ENR00776

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Synonyms

  • prostanoid EP1 receptor
  • EP1
  • PGE receptor, EP1 subtype
  • prostaglandin E2 receptor, EP1 subtype

General information

  • Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart. [1]
  • The dopaminergic cell loss is mediated by PGE2(Prostaglandin E2) acting through its receptors EP1. [2]
  • It is generally accepted that the EP1 receptor activates phospholipase C (PLC), which mediates activation of protein kinase C (PKC) and elevation of cytosolic free calcium [3]
  • The EP1 receptor binds PGE2 with a Kd of 21 nM which is higher than the 11.2 nM Kd for EP2 and the 2.9 nM Kd for EP3 [3]

Links to other resources

UniProt P34995
Ensembl ENST00000292513

Subunit information

Sequence 
MSPCGPLNL SLAGEATTC AAPWVPNTS 
AVPPSGASP ALPIFSMTL GAVSNLLAL 
ALLAQAAGR LRRRRSAAT FLLFVASLL 
ATDLAGHVI PGALVLRLY TAGRAPAGG 
ACHFLGGCM VFFGLCPLL LGCGMAVER 
CVGVTRPLL HAARVSVAR ARLALAAVA 
AVALAVALL PLARVGRYE LQYPGTWCF 
IGLGPPGGW RQALLAGLF ASLGLVALL 
AALVCNTLS GLALLRARW RRRSRRPPP 
ASGPDSRRR WGAHGPRSA SASSASSIA 
SASTFFGGS RSSGSARRA RAHDVEMVG 
QLVGIMVVS CICWSPMLV LVALAVGGW 
SSTSLQRPL FLAVRLASW NQILDPWVY 
ILLRQAVLR QLLRLLPPR AGAKGGPAG 
LGLTPSAWE ASSLRSSRH SGLSHF

Binding hormones

  • PGE1
    • Selectivity for prostanoid receptors: EP1=EP2=EP3=EP4 [4]
  • PGE2
    • Selectivity for prostanoid receptors: EP1=EP2=EP3=EP4 [4]

Anatomical structures with this receptor

  • kidney

  • lung

    Induced phenotypes

    • Pulmonary venous smooth muscle contraction

  • skeleton_muscle

  • spleen

  • cell_of_endometrium_of_uterus

  • oesophagus

    Induced phenotypes

    • visceral pain hypersensitivity
      • prostaglandine e2 receptor-1 mediates acid-induced visceral pain hypersensitivity in humans. [5]
    • acid-induced pain hypersensitivity within the non-acid-exposed esophagus (secondary hyperalgesia) is mediated by PGE(2) activation of the EP-1 receptor [5]
Reference